Xu Mengdan, Xu Keyang, Peng Wei, Ge Jianxian, Wang Ning, Yu Guangqiu, Wu Yongyou, Zeng Jianfeng
Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China.
Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Acta Biomater. 2025 Jun 15;200:47-66. doi: 10.1016/j.actbio.2025.05.043. Epub 2025 May 21.
Endoscopic Submucosal Dissection (ESD) has emerged as a pivotal technique for the minimally invasive treatment of early gastrointestinal cancers, offering benefits such as reduced trauma, lower complication rates, and cost-effectiveness. Despite its advantages, the selection of optimal biomaterials for submucosal injection poses significant challenges. Current materials used in clinical settings often suffer from rapid diffusion, requiring multiple injections and potentially causing localized inflammation. These issues underscore the importance of identifying more effective submucosal injection materials to minimize postoperative complications and enhance patient outcomes. Recent advancements have highlighted the potential of hydrogels in this context, favored for their ability to maintain mucosal elevation longer and support wound healing. This review comprehensively examines the development and application of hydrogels in ESD, focusing on their physicochemical properties, biocompatibility, and the clinical implications of their use. These issues discuss various formulations of hydrogels, their mechanisms of action, and comparative analyses with traditional materials. Furthermore, the review explores ongoing innovations and future perspectives in hydrogel research, aiming to catalyze further advancements in ESD techniques. STATEMENT OF SIGNIFICANCE: This review critically examines hydrogel technologies in endoscopic submucosal dissection for gastrointestinal cancers, highlighting their role in improving procedural outcomes and patient recovery. It explores hydrogels' ability to enhance mucosal elevation, reduce complications, and accelerate healing, offering insights into their transformative potential in medical treatments. The findings emphasize the development of innovative materials that could significantly advance clinical practices in gastrointestinal cancer management.
内镜黏膜下剥离术（ESD）已成为早期胃肠道癌微创治疗的关键技术，具有创伤小、并发症发生率低和成本效益高等优点。尽管具有这些优势，但选择最佳的黏膜下注射生物材料仍面临重大挑战。临床中使用的现有材料往往存在快速扩散的问题，需要多次注射，并可能导致局部炎症。这些问题凸显了识别更有效的黏膜下注射材料以尽量减少术后并发症并改善患者预后的重要性。最近的进展突出了水凝胶在这方面的潜力，因其能够更长时间地维持黏膜隆起并支持伤口愈合而受到青睐。本综述全面研究了水凝胶在ESD中的开发和应用，重点关注其物理化学性质、生物相容性及其使用的临床意义。这些问题讨论了水凝胶的各种配方、其作用机制以及与传统材料的比较分析。此外，本综述探讨了水凝胶研究中的持续创新和未来前景，旨在推动ESD技术的进一步发展。重要性声明：本综述批判性地研究了用于胃肠道癌内镜黏膜下剥离术的水凝胶技术，强调了它们在改善手术效果和患者恢复方面的作用。它探讨了水凝胶增强黏膜隆起、减少并发症和加速愈合的能力，深入了解了它们在医学治疗中的变革潜力。研究结果强调了创新材料的开发，这些材料可能会显著推进胃肠道癌管理的临床实践。
