美国国立卫生研究院2025年慢性移植物抗宿主病共识会议更新内容
NIH Chronic Graft-Versus-Host Disease Consensus Conference 2025 Update.
作者信息
Lee Stephanie J, Williams Kirsten M, Sarantopoulos Stefanie, Kitko Carrie L, Cutler Corey, Pidala Joseph, Hill Geoffrey R, DeFilipp Zachariah, Greinix Hildegard T, Wolff Daniel, Paczesny Sophie, Cuvelier Geoffrey D E, Schultz Kirk R, Pavletic Steven Z
机构信息
Clinical Research Division and Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.
Aflac Blood and Cancer Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta Georgia.
出版信息
Transplant Cell Ther. 2025 May 21. doi: 10.1016/j.jtct.2025.05.016.
In 2020, the third NIH Consensus Development Project on Criteria for Chronic Graft-versus-Host Disease (GVHD) Clinical Trials was held with the goals of identifying gaps in understanding, prevention and treatment of chronic graft-versus-host disease (GVHD) and making actionable recommendations that would advance the field. An interim meeting was held in October 2024 to review progress on the 2020 recommendations. Each group was charged with reviewing their previous recommendations, assessing whether the field is on track to eventually achieve the goals, and considering whether recommendations should be modified in light of new data or insufficient progress. This manuscript summarizes the Working Groups' reports and helps define the research agenda for future studies in chronic GVHD. Overall, modest progress has been made on most initiatives. Some studies in progress will address key recommendations and results are eagerly anticipated.
2020年，美国国立卫生研究院（NIH）召开了第三届慢性移植物抗宿主病（GVHD）临床试验标准共识发展项目会议，目的是找出在慢性移植物抗宿主病（GVHD）的理解、预防和治疗方面存在的差距，并提出可付诸行动的建议，以推动该领域的发展。2024年10月召开了一次中期会议，以审查2020年建议的进展情况。每个小组负责审查其先前的建议，评估该领域是否有望最终实现目标，并考虑是否应根据新数据或进展不足对建议进行修改。本手稿总结了各工作组的报告，并有助于确定慢性GVHD未来研究的议程。总体而言，大多数倡议都取得了一定进展。一些正在进行的研究将解决关键建议，人们热切期待研究结果。
Zotero 插件