Bou Fakhreddine Hisham, Zeineldine Salah, Itani Hassan, Sater Jawad Abdul, BouKhalil Pierre, Al Harfani Bassem, Bouakl Imad
Division of Pulmonary, Critical Care, Sleep Medicine, Department of Internal Medicine, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon.
Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon.
Respir Med. 2025 Aug;244:108173. doi: 10.1016/j.rmed.2025.108173. Epub 2025 May 21.
Post-COVID Syndrome (PCS) significantly impacts morbidity, impairing quality of life (QoL) and mental health. This study assesses PCS symptom prevalence, the impact of COVID-19 severity on QoL and mental health and identifies predictors of impaired QoL among COVID-19 survivors in Lebanon.
ology: The study included adult COVID-19 survivors who recovered at least 4 weeks before enrollment. Participants completed symptom questionnaires, 36-Item Short Form Health Survey (SF-36), and Hospital Anxiety Depression Scale (HADS) at enrollment and during follow-up visits. PCS symptoms prevalence, SF-36 and HADS scores were compared across infection severity groups. Multivariate linear regressions identified predictors of lower SF-36 scores.
The study included 417 patients, with 50.1 % being male and an average age of 48 years. Most patients (78 %) had mild COVID-19 and presented within 3 months of recovery (83 %). The most commonly reported symptoms were fatigue (54.3 %), dyspnea (47.5 %), cough (38.8 %), and palpitations (38.4 %). Dyspnea was more prevalent in severe cases (71.4 %) than in mild and moderate ones. Severe COVID-19 patients had significantly lower scores in physical function, role limitations due to physical health, and body pain compared to the mild group. Mild cases had higher abnormal HADS anxiety scores than moderate and severe cases, with no differences in HADS depression scores. The main independent predictors of impaired physical functioning and role limitations were severe COVID-19, fatigue, and dyspnea.
PCS severely impacts QoL and mental health, with impairment directly linked to the severity of acute infection and the persistence of symptoms.
新冠后综合征（PCS）对发病率有显著影响，损害生活质量（QoL）和心理健康。本研究评估了黎巴嫩新冠幸存者中PCS症状的患病率、新冠严重程度对生活质量和心理健康的影响，并确定了生活质量受损的预测因素。
该研究纳入了在入组前至少已康复4周的成年新冠幸存者。参与者在入组时和随访期间完成了症状问卷、36项简短健康调查（SF-36）和医院焦虑抑郁量表（HADS）。比较了不同感染严重程度组的PCS症状患病率、SF-36和HADS评分。多变量线性回归确定了SF-36评分较低的预测因素。
该研究纳入了417例患者，其中50.1%为男性，平均年龄为48岁。大多数患者（78%）患有轻度新冠，并在康复后3个月内就诊（83%）。最常报告的症状是疲劳（54.3%）、呼吸困难（47.5%）、咳嗽（38.8%）和心悸（38.4%）。呼吸困难在重症病例（71.4%）中比在轻症和中症病例中更常见。与轻症组相比，重症新冠患者在身体功能、因身体健康导致的角色限制和身体疼痛方面的得分显著更低。轻症病例的HADS焦虑异常评分高于中症和重症病例，HADS抑郁评分无差异。身体功能受损和角色限制的主要独立预测因素是重症新冠、疲劳和呼吸困难。
PCS严重影响生活质量和心理健康，损害与急性感染的严重程度和症状的持续存在直接相关。
