血管内生殖细胞肿瘤累及心脏及双侧肺动脉

Intravascular Germ Cell Tumor With Cardiac and Bilateral Pulmonary Artery Involvement.

作者信息

Calderon-Miranda Camilo Andres, Reyes-Cardona Maria Juliana, Lopez-Mora Gabriel Roberto, Cadavid-Alvear Eduardo Alberto, Vesga-Reyes Carlos Enrique, Sanchez-Blanco Jairo, Olaya Pastor, Zambrano-Franco Jorge Alexander

机构信息

Departamento de Cardiología, Fundación Valle del Lili, Cali, Colombia; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.

Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.

出版信息

JACC Case Rep. 2025 May 21;30(11):103319. doi: 10.1016/j.jaccas.2025.103319. Epub 2025 Apr 9.

DOI:10.1016/j.jaccas.2025.103319

PMID:40409851

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12243050/

Abstract

BACKGROUND

Germ cell tumors (GCTs) are neoplasms usually originating in the gonads, most often affecting young patients. Intravascular GCTs are exceptionally rare and potentially fatal due to cardiac and embolic complications.

CASE SUMMARY

A 17-year-old patient presented with weight loss, abdominal pain, and dyspnea. Imaging revealed an intravascular mass extending from the inferior vena cava (IVC) into the right heart chambers and pulmonary arteries. The tumor was successfully removed via surgery under cardiopulmonary bypass. Histopathologic diagnosis was a mixed non-seminomatous GCT. Recovery was uneventful, and follow-up imaging showed no intravascular lesions. Cisplatin-based chemotherapy was started with curative intent.

DISCUSSION

Intravascular GCT is a rare phenomenon, presenting mostly with retroperitoneal disease affecting the IVC. Cardiologists assess complications and interpret cardiovascular imaging. A multidisciplinary approach is crucial for improving outcomes.

摘要