Aronson Jenny R, Justo Julie Ann, Amanatullah Derek F
Division of Infectious Diseases and Geographic Medicine, Department of Medicine, School of Medicine, Stanford University, 300 Pasteur Drive, L-134, Stanford, CA 94305, USA.
Division of Infectious Diseases, Department of Pharmacy, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA. Electronic address: https://twitter.com/julie_justo.
Infect Dis Clin North Am. 2025 Sep;39(3):529-547. doi: 10.1016/j.idc.2025.03.002. Epub 2025 May 22.
This article explores the role of local antibiotic delivery in the management of orthopedic infections, a significant challenge in modern healthcare. This article delineates between prophylactic and therapeutic uses of antibiotics, examining various delivery methods, including topical powders, irrigation solutions, intraosseous injections, and antibiotic-loaded bone cement. While local administration aims to enhance therapeutic efficacy and minimize systemic exposure, there is limited evidence supporting effectiveness. The article aims to review the current practices and evidence and highlight emerging strategies such as hydrogels and biodegradable systems. Ongoing research is essential to optimize these methods and improve patient outcomes in orthopedic care.
本文探讨了局部抗生素递送在骨科感染管理中的作用，这是现代医疗保健中的一项重大挑战。本文阐述了抗生素的预防性和治疗性用途，研究了各种递送方法，包括局部粉末、冲洗液、骨内注射和载抗生素骨水泥。虽然局部给药旨在提高治疗效果并尽量减少全身暴露，但支持其有效性的证据有限。本文旨在回顾当前的实践和证据，并强调水凝胶和可生物降解系统等新兴策略。持续的研究对于优化这些方法和改善骨科护理中的患者预后至关重要。
