诊断时的免疫衰老决定儿童白血病幸存者的T细胞恢复情况。

Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors.

作者信息

Dhodapkar Kavita M, Castellino Sharon, Kapadia Shivani, Azeem Maryam I, Horvat Ava, Lawrence Taylor, DeRyckere Deborah, Dhodapkar Madhav V

机构信息

Division of Translational Science and Therapeutics, Fred Hutch Cancer Center, Seattle, WA, USA.

Department of Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, WA, USA.

出版信息

NPJ Aging. 2025 May 23;11(1):39. doi: 10.1038/s41514-025-00233-0.

DOI:10.1038/s41514-025-00233-0

PMID:40410231

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12102316/

Abstract

We show that T cells in survivors of childhood leukemia exhibit distinct profiles dominated by aging-associated changes and consistent with premature immune aging. Immune profiles during survivorship in biospecimens (n = 251) from uniformly-treated children with B-acute lymphoblastic leukemia recapitulate heterogeneity at diagnosis in individual patients and correlate with genetic-risk subtypes. These data suggest that pre-therapy immune aging may determine variance in immune status during survivorship.

摘要

我们发现，儿童白血病幸存者体内的T细胞呈现出独特的特征，这些特征主要由与衰老相关的变化主导，并且与免疫早衰一致。在接受统一治疗的B型急性淋巴细胞白血病患儿的生物样本（n = 251）中，存活期的免疫特征概括了个体患者诊断时的异质性，并与遗传风险亚型相关。这些数据表明，治疗前的免疫衰老可能决定存活期免疫状态的差异。