Kritzler R K, Plotnick L P
Postgrad Med. 1985 Sep 15;78(4):51-9. doi: 10.1080/00325481.1985.11699137.
Short stature is less likely to have an endocrine basis than is commonly thought. Any of a number of chronic systemic diseases can slow growth, short stature may result from a genetic tendency or disorder, growth may be constitutionally delayed, or it may be retarded by intrauterine influences. True endocrine causes include thyroid or adrenal disorder, growth hormone deficiency, and psychosocial dwarfism. Although growth hormone deficiency is quite rare, it has received increased attention recently. The capability to produce human growth hormone by recombinant DNA techniques presents the prospect that replacement therapy will be more readily available to those patients who might benefit from it. Caution is called for, however, in making use of this agent for patients other than those with proven growth hormone deficiency.
身材矮小由内分泌因素引起的可能性比通常认为的要小。许多慢性全身性疾病中的任何一种都可能减缓生长，身材矮小可能源于遗传倾向或疾病，生长可能是体质性延迟，也可能受到子宫内因素的阻碍。真正的内分泌原因包括甲状腺或肾上腺疾病、生长激素缺乏以及心理社会侏儒症。虽然生长激素缺乏相当罕见，但最近受到了更多关注。通过重组DNA技术生产人生长激素的能力带来了一种前景，即替代疗法将更容易提供给那些可能从中受益的患者。然而，对于除了已证实生长激素缺乏的患者之外的其他患者使用这种药物时需要谨慎。
