Huang Zhen, Ling Wen, Lyu Guorong, Xu Shuxia, Ye Fengying, Fang Yifan, Weng Zongjie, Wu Qiumei
Department of Pathology, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, China.
Department of Medical Ultrasonics, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, China.
BMC Gastroenterol. 2025 May 23;25(1):398. doi: 10.1186/s12876-025-03972-2.
To perform correlation analyses between the ultrasonographic characteristics of porta hepatis lymph nodes (PHLNs) and the pathological features of PHLNs and the liver in biliary atresia (BA).
We analyzed the clinical ultrasonographic characteristics of PHLNs in 27 patients with BA, along with specific pathological features, including pathological size, the number of bile granules, the number of germinal centers, the proportion of lymphocytes, and the analysis of liver biopsy specimens. A series of correlation analyses were then performed between ultrasonography data, pathological features, and prognosis.
The level of ultrasound echogenicity of PHLNs was positively correlated with the number of bile granules (r = 0.377, p = 0.004), while ultrasound and pathological size were also positively correlated with the number of germinal centers (r = 0.591, p = 0.001; r = 0.459, p = 0.016, respectively). No significant correlations were detected between the stage of liver fibrosis and pathological features or postoperative jaundice (all p > 0.05). Different types of lymphocytes proliferating in the livers, and CD8 + cells were positively correlated with the pathological size of PHLNs (r = 0.390, p = 0.045; r = 0.424, p = 0.028, respectively), and the number of germinal centers(r = 0.554, p = 0.003; r = 0.482, p = 0.011, respectively).The ultrasonographic and pathological size of PHLNs were only positively correlated with the serum levels of direct bilirubin(r = 0.431, p = 0.025; r = 0.593, p = 0.001, respectively).Finally, the pathological size of PHLNs and the number of CD8 + cells in the liver were negatively correlated with the reduction of jaundice following Kasai portoenterostomy (KPE) surgery (r=-0.385, p = 0.047; r=-0.567, p = 0.0411; r=-0.002, p = 0.033, respectively).
Analyses demonstrated that the ultrasonographic features of PHLNs are significantly correlated with pathological features of PHLNs and the liver. In addition, the enlargement of PHLNs might represent a prognostic predictor following KPE surgery.
对胆道闭锁（BA）患者肝门淋巴结（PHLNs）的超声特征与PHLNs及肝脏的病理特征进行相关性分析。
我们分析了27例BA患者PHLNs的临床超声特征，以及特定的病理特征，包括病理大小、胆汁颗粒数量、生发中心数量、淋巴细胞比例，以及肝活检标本分析。然后对超声数据、病理特征和预后进行了一系列相关性分析。
PHLNs的超声回声水平与胆汁颗粒数量呈正相关（r = 0.377，p = 0.004），而超声和病理大小也与生发中心数量呈正相关（分别为r = 0.591，p = 0.001；r = 0.459，p = 0.016）。未检测到肝纤维化分期与病理特征或术后黄疸之间存在显著相关性（所有p>0.05）。肝脏中增殖的不同类型淋巴细胞，CD8 +细胞与PHLNs的病理大小呈正相关（分别为r = 0.390，p = 0.045；r = 0.424，p = 0.028），以及与生发中心数量呈正相关（分别为r = 0.554，p = 0.003；r = 0.482，p = 0.011）。PHLNs的超声和病理大小仅与直接胆红素血清水平呈正相关（分别为r = 0.431，p = 0.025；r = 0.593，p = 0.001）。最后，PHLNs的病理大小和肝脏中CD8 +细胞数量与Kasai肝门空肠吻合术（KPE）后黄疸的消退呈负相关（分别为r = -0.385，p = 0.047；r = -0.567，p = 0.0411；r = -0.002，p = 0.033）。
分析表明，PHLNs的超声特征与PHLNs及肝脏的病理特征显著相关。此外，PHLNs增大可能是KPE手术后的预后预测指标。
