Tasli Nurdan Gamze, Gunay Betul Onal, Ugurlu Adem, Eren Mehtap Arslanturk, Aykut Murat, Esenülkü Cenap Mahmut
Department of Ophthalmology, University of Health Sciences, Trabzon Kanuni Training and Resarch Hospital, Trabzon, Turkey.
Department of Ophthalmology, College of Medicine, Erzincan Binali Yıldırım University Hospital, Erzincan, Turkey.
BMC Ophthalmol. 2025 May 23;25(1):311. doi: 10.1186/s12886-025-04136-2.
To investigate retinal thickness and vascular structure in patients with non-alcoholic fatty liver disease (NAFLD) using optical coherence tomography (OCT) and OCT angiography (OCTA) and to compare the results with healthy controls.
The medical records of NAFLD patients were retrospectively reviewed. Macular thickness (MT) and peripapillary retinal nerve fibre layer (pRNFL) thickness were assessed. The vessel density (VD) of Superficial Capillary Plexus (SCP), Deep Capillary Plexus (DCP), foveal avascular zone (FAZ) area, FAZ circularity index (CI), and FAZ perimeter were also recorded.
The study included 64 patients with NAFLD and 64 healthy controls. Mean MT and pRNFLT were similar between groups. The study group showed a significant reduction in VD-DCP compared to the control group (36.0 ± 5.2 vs. 38.5 ± 4.1, p < 0.001). Total FAZ area was greater in the study group than in the control group (0.42 ± 0.10 vs. 0.33 ± 0.12mm2, p < 0.001). FAZ CI also differed between groups (0.47 ± 0.08 vs. 0.53 ± 0.08, p < 0.001). Enlarged FAZ area and decreased VD-DCP were significantly associated with NAFLD severity.
Individuals with NAFLD have certain changes in the retinal microvasculature, including reduced VD-DCP, an increased FAZ area, and a decreased of FAZ CI. The variations in VD-DCP and FAZ area exhibit discrepancies according to the disease grade. There are some limitations, including its retrospective nature, the small number of participants, the lack of analysis of the peripapillary area, and the lack of examination of longitudinal changes.
使用光学相干断层扫描（OCT）和OCT血管造影（OCTA）研究非酒精性脂肪性肝病（NAFLD）患者的视网膜厚度和血管结构，并将结果与健康对照者进行比较。
回顾性分析NAFLD患者的病历。评估黄斑厚度（MT）和视乳头周围视网膜神经纤维层（pRNFL）厚度。还记录了浅表毛细血管丛（SCP）、深部毛细血管丛（DCP）的血管密度（VD）、中心凹无血管区（FAZ）面积、FAZ圆形度指数（CI）和FAZ周长。
该研究纳入了64例NAFLD患者和64例健康对照者。两组之间的平均MT和pRNFLT相似。与对照组相比，研究组的VD-DCP显著降低（36.0±5.2 vs. 38.5±4.1，p<0.001）。研究组的总FAZ面积大于对照组（0.42±0.10 vs. 0.33±0.12mm²，p<0.001）。两组之间的FAZ CI也存在差异（0.47±0.08 vs. 0.53±0.08，p<0.001）。FAZ面积增大和VD-DCP降低与NAFLD严重程度显著相关。
NAFLD患者的视网膜微血管存在一定变化，包括VD-DCP降低、FAZ面积增加和FAZ CI降低。VD-DCP和FAZ面积的变化根据疾病分级存在差异。存在一些局限性，包括研究的回顾性、参与者数量少、缺乏对视乳头周围区域的分析以及缺乏对纵向变化的检查。
