Taraballi Francesca, Corbo Claudia, Enterria-Rosales Julia, Martinez John Otto, Minardi Silvia, Pandolfi Laura, Wang Xing, Tasciotti Ennio, Singh Kavindra V, Arias Cesar A, Corradetti Bruna
Center for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, TX, USA.
Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston, TX, USA.
Adv Sci (Weinh). 2025 Aug;12(31):e2415364. doi: 10.1002/advs.202415364. Epub 2025 May 24.
Small alterations during the early stages of the innate immune response to an implant can drive large changes in adaptive immunity. Biomaterials for regenerative purposes can be engineered to modulate this immune response in beneficial ways. This study presents an innovative patch designed and functionalized to target the innate immunity at the implant site. Mannose moieties are incorporated into collagen patches, resulting in a technology called Local Immunotuning Patch (LIP), designed to directly interact with antigen presenting cells through their mannose receptor. In vitro, LIP shows anti-inflammatory effects on bone marrow-derived macrophages and inhibitory properties even on methicillin-resistant bacterial strains. Subcutaneous implantation in mice reveals that LIP modulates multiple pathways related to innate and adaptive immunity, underscoring its role in shaping an immune-engineered environment around the implant. These findings highlight the potential of this strategy to control the foreign body reaction at the implant site, making it applicable for various uses, including wound healing and surgical infection control in reconstructive procedures.
在对植入物的先天性免疫反应早期阶段的微小改变，可推动适应性免疫发生巨大变化。用于再生目的的生物材料可以通过工程设计以有益的方式调节这种免疫反应。本研究展示了一种创新的贴片，其设计并功能化以靶向植入部位的先天性免疫。甘露糖部分被整合到胶原蛋白贴片中，产生了一种名为局部免疫调节贴片（LIP）的技术，旨在通过其甘露糖受体与抗原呈递细胞直接相互作用。在体外，LIP对骨髓来源的巨噬细胞显示出抗炎作用，甚至对耐甲氧西林细菌菌株也具有抑制特性。在小鼠皮下植入表明，LIP调节与先天性和适应性免疫相关的多种途径，突出了其在塑造植入物周围免疫工程环境中的作用。这些发现凸显了该策略在控制植入部位异物反应方面的潜力，使其适用于各种用途，包括伤口愈合和重建手术中的手术感染控制。
