Michelini Simone, Greco Maria Elisabetta, Vespasiani Giordano, Trovato Federica, Chello Camilla, Musolff Noah, Cantisani Carmen, Pellacani Giovanni
Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.
Dermatology Department, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.
Skin Res Technol. 2025 Feb-May;31(2-5):e70171. doi: 10.1111/srt.70171.
Skin aging represents a para-physiological process related to metabolic imbalances, inflammation, proliferative responses, and oxidative stress. Ending the cycle of inflammation, and oxidative stress represents a way to slow the effects of aging.
The aim of our study was to evaluate the benefits of supplements with an herbal mixture based on Venerinase and B-group vitamins, Zinc, and Magnesium in preventing/reducing photoaging by means of objective quantitative analysis of visual skin features obtained by VISIA 2D and stroma and vascular characteristics measured by Optical Coherence Tomography (OCT).
A prospective clinical study was conducted in 40 participants. They were randomized 1:1 to receive the supplement (Giovina) or placebo. Assessments were conducted at Baseline (T0), after 2 months (T1), and after 4 months (T2). The primary endpoint was to obtain a significant improvement in facial photo/chrono-aging in the treatment arm, as assessed through the evaluation of the Griffith scale. Secondary endpoints were to assess significant changes in skin aging objective features (VISIA) and Optical Coherence Tomography (OCT) parameters.
The treated group showed a significant reduction in the mean Griffith scale score from 4.5 at baseline to 3.76 at T2 (4 months) (p = 0.001). A significant decrease in red areas and a borderline significant reduction in the number of wrinkles have been shown by skin aging objective feature calculation on VISIA 2D photographs. OCT analysis showed a borderline significant reduction in collagen density.
The decrease in vascular pattern and collagen density suggests an anti-inflammatory effect with a potential stromal remodeling in the treated group. This seems to be correlated to the reduction in wrinkles and facial redness.
皮肤老化是一个与代谢失衡、炎症、增殖反应和氧化应激相关的准生理过程。终止炎症和氧化应激循环是减缓衰老影响的一种方式。
我们研究的目的是通过对VISIA 2D获得的视觉皮肤特征以及光学相干断层扫描（OCT）测量的基质和血管特征进行客观定量分析，评估含有基于维纳酶、B族维生素、锌和镁的草药混合物的补充剂在预防/减少光老化方面的益处。
对40名参与者进行了一项前瞻性临床研究。他们被1:1随机分组，分别接受补充剂（乔维娜）或安慰剂。在基线（T0）、2个月后（T1）和4个月后（T2）进行评估。主要终点是通过格里菲斯量表评估，使治疗组面部光老化/自然老化得到显著改善。次要终点是评估皮肤老化客观特征（VISIA）和光学相干断层扫描（OCT）参数的显著变化。
治疗组的平均格里菲斯量表评分从基线时的4.5显著降至T2（4个月）时的3.76（p = 0.001）。通过对VISIA 2D照片进行皮肤老化客观特征计算，结果显示红色区域显著减少，皱纹数量有临界显著减少。OCT分析显示胶原密度有临界显著降低。
血管模式和胶原密度的降低表明治疗组具有抗炎作用，并可能伴有基质重塑。这似乎与皱纹和面部发红的减少相关。
