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希腊基层医疗环境中接受常规治疗的2型糖尿病患者心血管和肾脏合并症的患病率:一项流行病学研究(RE CARDIA研究)

Prevalence of cardiovascular and renal comorbidities among patients with type 2 diabetes routinely treated in the primary care setting in Greece: An epidemiological study (the RECARDIA study).

作者信息

Papanas Nikolaos, Tsimihodimos Vasileios, Katsiki Niki, Doupis John, Pagkalos Emmanouil, Nikas Nikos, Papakonstantopoulos Nikos, Karpouzos George, Tentolouris Nikolaos

机构信息

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.

Department of Internal Medicine, School of Health Sciences, Department of Medicine, University of Ioannina, Ioannina, Greece.

出版信息

J Diabetes Complications. 2025 Aug;39(8):109087. doi: 10.1016/j.jdiacomp.2025.109087. Epub 2025 May 21.

Abstract

AIMS

This study aimed to generate real-world data on the prevalence of cardiovascular disease (CVD), including atherosclerotic CVD (ASCVD) and heart failure (HF), as well as chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) routinely treated in Greece.

METHODS

This was a non-interventional, epidemiological, multicentre, cross-sectional and retrospective chart review study of T2DM patients attending a routine clinical visit at 198 outpatient primary care settings across Greece from November 2020 to February 2022.

RESULTS

Among 2000 enrolled T2DM outpatients, the prevalence of ASCVD was 20.40 % (95 % confidence interval [CI]: 18.67 %-22.25 %), of HF 8.03 % (95 % CI: 6.67 %-9.63 %), and of CKD 49.55 % (95 % CI: 47.36 %-51.74 %). Hypertension was correlated with increased risk of ASCVD, HF or CKD, dyslipidaemia with ASCVD and CKD, obesity solely with HF, and smoking with ASCVD. Patients over 65 years were at higher risk of ASCVD, HF or CKD, whereas those with T2DM for ≥10 years had a higher risk of ASCVD or HF. Finally, males were more likely to have ASCVD CONCLUSIONS: The present study confirms the high prevalence of CVD and CKD among Greek T2DM patients managed in primary care, that potentially qualify for new antidiabetic treatments with cardiovascular or renal benefits.

摘要

目的

本研究旨在生成关于希腊常规治疗的2型糖尿病(T2DM)患者心血管疾病(CVD)患病率的真实世界数据,包括动脉粥样硬化性心血管疾病(ASCVD)和心力衰竭(HF),以及慢性肾脏病(CKD)。

方法

这是一项对2020年11月至2022年2月期间在希腊198个门诊初级保健机构进行常规临床就诊的T2DM患者进行的非干预性、流行病学、多中心、横断面和回顾性图表审查研究。

结果

在2000名登记的T2DM门诊患者中,ASCVD的患病率为20.40%(95%置信区间[CI]:18.67%-22.25%),HF为8.03%(95%CI:6.67%-9.63%),CKD为49.55%(95%CI:47.36%-51.74%)。高血压与ASCVD、HF或CKD风险增加相关,血脂异常与ASCVD和CKD相关,肥胖仅与HF相关,吸烟与ASCVD相关。65岁以上的患者患ASCVD、HF或CKD的风险更高,而T2DM病程≥10年的患者患ASCVD或HF的风险更高。最后,男性更有可能患ASCVD。结论:本研究证实了在初级保健中管理的希腊T2DM患者中CVD和CKD的高患病率,这些患者可能有资格接受具有心血管或肾脏益处的新型抗糖尿病治疗。

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