Kim Sung-Hee, Lee Kyoung-Ki, Lee Ilseob, Shin Go-Eun, Jang Ji-Ung, Joo Yoon-A, Lee Kyunghyun, Kim Ah-Young, Ku Bok-Kyung, Jeoung Hye-Young
Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea.
Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea.
Biologicals. 2025 Aug;91:101844. doi: 10.1016/j.biologicals.2025.101844. Epub 2025 May 23.
Feline coronavirus is highly contagious and ubiquitous in cat populations. FCoV is classified into two serotypes, types I and II, each including two biotypes, feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV)In this study, FCoV detected in samples collected by the Animal and Plant Quarantine Agency from 2016 to 2023, and analyzed genetic diversity of FCoV for currently circulation in Korea. In a total of 925 cats, FCoV was detected in 294 cats (31.8 %). Among the 73 cases with a final diagnosis, 47.9 % (35/73) were finally found to be FIPV, and 52.1 % (38/73) were confirmed to be FECV. Of the 294 FCoV-positive cases, 24 partial S genes were successfully sequenced. Partial S2 subunit sequencing indicated that types I and II accounted for 91.7 % (22/24) and 8.3 % (2/24) of the cases, respectively. One case, 23D103, contained a different six-nucleotide deletion in the S gene. Phylogenetic analysis of types I and II showed clear discrimination based on the S gene. Types I and II also exhibited 63.2-99.8 % nucleotide acid homology with the S gene of the reference strains. This study provides updated information regarding the current infection status and molecular characteristics of FCoV in Korea.
猫冠状病毒在猫群体中具有高度传染性且普遍存在。猫冠状病毒分为I型和II型两种血清型，每种血清型又包括两种生物型，即猫肠道冠状病毒（FECV）和猫传染性腹膜炎病毒（FIPV）。在本研究中，对动植物检疫机构于2016年至2023年采集的样本中检测到的猫冠状病毒进行分析，以了解韩国目前流行的猫冠状病毒的遗传多样性。在总共925只猫中，294只猫（31.8%）检测到猫冠状病毒。在73例最终确诊病例中，最终发现47.9%（35/73）为猫传染性腹膜炎病毒，52.1%（38/73）为猫肠道冠状病毒。在294例猫冠状病毒阳性病例中，成功对24个部分S基因进行了测序。部分S2亚基测序表明，I型和II型分别占病例的91.7%（22/24）和8.3%（2/24）。其中一个病例23D103的S基因存在不同的6个核苷酸缺失。I型和II型的系统发育分析显示基于S基因有明显区分。I型和II型与参考菌株的S基因也表现出63.2%-99.8%的核苷酸同源性。本研究提供了有关韩国猫冠状病毒当前感染状况和分子特征的最新信息。
