Noujaim Charbel, Tabaja Chadi, Wazni Oussama M, Santangeli Pasquale
Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.
Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.
Card Electrophysiol Clin. 2025 Jun;17(2):137-145. doi: 10.1016/j.ccep.2025.02.002. Epub 2025 Mar 11.
Pulsed field ablation (PFA) has emerged as a promising, nonthermal technique for arrhythmia ablation, leveraging high-voltage electrical fields to induce electroporation and create precise ablation lesions. Unlike traditional thermal methods such as radiofrequency ablation (RFA) and cryoablation, PFA selectively targets myocardial cells while sparing surrounding tissues, reducing the risk of collateral damage. This review focuses on the key characteristics of PFA lesion formation, drawing comparisons with RFA and cryoablation based on histopathology, imaging, and electroanatomical mapping.
脉冲场消融（PFA）已成为一种有前景的非热心律失常消融技术，利用高压电场诱导电穿孔并形成精确的消融灶。与传统的热消融方法如射频消融（RFA）和冷冻消融不同，PFA选择性地靶向心肌细胞，同时保护周围组织，降低了附带损伤的风险。本综述重点关注PFA病灶形成的关键特征，并基于组织病理学、影像学和电解剖标测与RFA和冷冻消融进行比较。
