Petru Jan, Funasako Moritoshi, Neuzil Petr
Department of Cardiology, Charles University, Na Homolce Hospital, Roentgenova 2, 150 30, Prague 5, Prague, Czech Republic.
Department of Cardiology, Charles University, Na Homolce Hospital, Roentgenova 2, 150 30, Prague 5, Prague, Czech Republic.
Card Electrophysiol Clin. 2025 Jun;17(2):273-285. doi: 10.1016/j.ccep.2025.02.015. Epub 2025 Mar 17.
Pulse field ablation (PFA) has gained attention in the field of atrial fibrillation catheter treatment recently. All currently used or developed technologies use ultrashort pulses (on the order of microseconds). The Emerging CellFX System (Pulse Biosciences, Inc, Inc) utilizes nanosecond PFA (nsPFA) and is thus several orders of magnitude shorter than the initial PFA systems. There are several potential advantages of nsPFA over microsecond PFA such as deeper penetration of the electric field into tissue, creating larger and deeper ablation zones while depositing less overall energy and heat, faster treatment, and less muscle stimulation or nerve capture.
脉冲场消融（PFA）最近在心房颤动导管治疗领域受到关注。目前所有使用或研发的技术都采用超短脉冲（微秒级）。新兴的CellFX系统（脉冲生物科学公司）采用纳秒级脉冲场消融（nsPFA），因此比最初的PFA系统短几个数量级。与微秒级PFA相比，nsPFA具有几个潜在优势，如电场对组织的穿透更深，能形成更大、更深的消融区，同时总体能量和热量沉积更少，治疗速度更快，肌肉刺激或神经捕捉更少。
