过氧化物酶体增殖物激活受体（PPARs）家族成员在痤疮中的作用。

The role of PPARs family members in acne.

作者信息

Zhang Shaoyang, Yang Yating, Yang Li, Meng Fangyu, Mu Yizhe, Yuan Yuhang, Zhang Yuan

机构信息

Yunnan Key Laboratory of Breast Cancer Precision Medicine, Academy of Biomedical Engineering, Kunming Medical University, Kunming, China.

出版信息

J Dermatol Sci. 2025 Jul;119(1):3-8. doi: 10.1016/j.jdermsci.2025.04.003. Epub 2025 May 23.

DOI:10.1016/j.jdermsci.2025.04.003

PMID:40413060

Abstract

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that play a crucial role in the genetic regulation of lipid metabolism and energy homeostasis. There is increasing evidence to suggest that PPARs may have a significant impact on the development and progression of acne, including its role in regulating lipid production, inhibiting keratinocyte proliferation, and reducing acne-related inflammation. As such, PPARs present themselves as promising therapeutic targets for both the prevention and treatment of acne. This article provides an overview of the role of PPARs in the pathological processes underlying acne, with particular emphasis on inflammation and lipid regulation.

摘要

过氧化物酶体增殖物激活受体（PPARs）是配体激活的转录因子，在脂质代谢和能量稳态的基因调控中起关键作用。越来越多的证据表明，PPARs可能对痤疮的发生和发展有重大影响，包括其在调节脂质生成、抑制角质形成细胞增殖以及减轻痤疮相关炎症方面的作用。因此，PPARs有望成为预防和治疗痤疮的治疗靶点。本文概述了PPARs在痤疮潜在病理过程中的作用，尤其着重于炎症和脂质调节方面。