长效匹那地尔对动脉内血压的影响。
The effects of long-acting pinacidil on intra-arterial blood pressure.
作者信息
Caruana M P, Al-Khawaja I, Royston P, Raftery E B
出版信息
Br J Clin Pharmacol. 1985 Aug;20(2):140-3. doi: 10.1111/j.1365-2125.1985.tb05045.x.
Abstract
We have tested the efficacy of a new long-acting preparation of pinacidil, an arterial vasodilator, using continuous intra-arterial ambulatory blood pressure recording. An acute dose produced a measurable effect lasting for 12 h. The duration of this effect was less during chronic twice daily drug administration. Side effects were common, causing two out of nine patients to withdraw from the study. Tilt testing produced no postural hypotension and there was no evidence of rebound hypertension on the withdrawal day.
摘要
我们使用连续动脉动态血压记录法，测试了新型长效制剂吡那地尔（一种动脉血管扩张剂）的疗效。急性给药剂量产生了持续12小时的可测量效果。在每日两次的慢性药物给药期间，这种效果的持续时间较短。副作用很常见，导致9名患者中有2名退出研究。倾斜试验未产生体位性低血压，且在停药日没有反弹性高血压的证据。
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Immediate central and peripheral haemodynamic effects of a new vasodilating agent Pinacidil (P1134) in hypertensive man.新型血管扩张剂匹那地尔（P1134）对高血压患者即刻的中心和外周血流动力学影响
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Preliminary evaluation of pinacidil in hypertension.匹那地尔治疗高血压的初步评估。
Br J Clin Pharmacol. 1983 Sep;16(3):336-8. doi: 10.1111/j.1365-2125.1983.tb02171.x.
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Pinacidil monotherapy for hypertension.吡那地尔单药治疗高血压。
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Drug therapy. Hydralazine.药物治疗。肼屈嗪。
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