单剂量和多剂量酮康唑对正常受试者肾上腺功能的影响。
Effects of single and multiple doses of ketoconazole on adrenal function in normal subjects.
作者信息
Bradbrook I D, Gillies H C, Morrison P J, Robinson J, Rogers H J, Spector R G
出版信息
Br J Clin Pharmacol. 1985 Aug;20(2):163-5. doi: 10.1111/j.1365-2125.1985.tb05051.x.
Abstract
The plasma cortisol response to 0.25 mg tetracosactrin given by intramuscular injection was suppressed by nine oral doses of 200 mg ketoconazole given 12 hourly to nine normal female subjects. No effect was noted following a single 200 mg oral dose of ketoconazole. This suppressive effect was reversible within at least 5 days of discontinuation of ketoconazole.
摘要
对9名正常女性受试者每12小时口服9次200毫克酮康唑后，肌肉注射0.25毫克替可克肽引起的血浆皮质醇反应受到抑制。单次口服200毫克酮康唑后未观察到效果。在停用酮康唑至少5天内，这种抑制作用是可逆的。
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