Ghani A M, Krause J R
Br J Haematol. 1985 Oct;61(2):203-13. doi: 10.1111/j.1365-2141.1985.tb02819.x.
Bone marrow biopsies from 13 cases of lymph-node-biopsy-proven angioimmunoblastic lymphadenopathy (AILD) were studied. Eight cases (62%) showed a characteristic 'granulomatoid' lymphoreticular infiltrate composed of a mixture of lymphocytes, epithelioid histiocytes, immunoblasts, plasma cells and eosinophils in varying proportions. Proliferation of blood vessels, although much less prominent than that described in lymph nodes, and a marked degree of reticulin fibrosis were also noted. The pattern of involvement was mainly focal and rarely diffuse. The foci were either single or multiple, and were distributed throughout the marrow but were only rarely paratrabecular. The associated haematopoietic marrow findings were nonspecific regardless of degree of bone marrow involvement. The histopathology of involved bone marrows in angioimmunoblastic lymphadenopathy is such that in some cases it should strongly suggest the diagnosis even in the absence of a prior definitive lymph node biopsy. Differentiating features from other disorders that might be confused with AILD are discussed. Survival rate was adversely affected by bone marrow involvement.
对13例经淋巴结活检证实为血管免疫母细胞性淋巴结病（AILD）的患者进行了骨髓活检研究。8例（62%）显示出特征性的“肉芽肿样”淋巴网状浸润，由淋巴细胞、上皮样组织细胞、免疫母细胞、浆细胞和嗜酸性粒细胞以不同比例混合而成。血管增生虽然不如淋巴结中描述的那样显著，但也观察到明显程度的网状纤维增生。累及模式主要为局灶性，很少为弥漫性。病灶可为单个或多个，分布于整个骨髓，但很少位于小梁旁。无论骨髓受累程度如何，相关的造血骨髓表现均无特异性。血管免疫母细胞性淋巴结病累及骨髓的组织病理学特征是，在某些情况下，即使没有先前明确的淋巴结活检，也应强烈提示诊断。文中讨论了与可能与AILD混淆的其他疾病的鉴别特征。骨髓受累对生存率有不利影响。
