衰老的人类红细胞表现出阴离子交换增加。

Aged human erythrocytes exhibit increased anion exchange.

作者信息

Zanner M A, Galey W R

出版信息

Biochim Biophys Acta. 1985 Sep 10;818(3):310-5. doi: 10.1016/0005-2736(85)90004-5.

Abstract

Young and old erythrocytes show different rate constants of anion exchange as measured by 35SO4(2-) efflux at 37 degrees C. Results indicate that the rate constant for 35SO4(2-) efflux (SO2-4-Cl- exchange) from old cells is approximately 20% greater than from young less dense cells. The cell water volume of older cells is also decreased. Based on these results and previously reported decreases of cell membrane area in aged cells we conclude that anion exchange (35SO4(2-)) is increased in older, more dense human erythrocytes.

摘要

通过在37℃下测量35SO4(2-)外流，发现年轻和衰老红细胞表现出不同的阴离子交换速率常数。结果表明，衰老细胞中35SO4(2-)外流（SO2-4-Cl-交换）的速率常数比年轻的低密度细胞大约高20%。衰老细胞的细胞水体积也有所减少。基于这些结果以及先前报道的衰老细胞中细胞膜面积的减少，我们得出结论：在更致密的衰老人类红细胞中，阴离子交换（35SO4(2-)）增加。