Chen Wen, Yang Lan, Zhang Xinyu, Ren Le, Wang Chucan, Wang Jiayi, Zheng Xinyao, Wu Jinfang
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, PR China.
National Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, Zhejiang, PR China; Amcare Women's and Children's Hospital, Beijing, PR China.
Cont Lens Anterior Eye. 2025 Oct;48(5):102446. doi: 10.1016/j.clae.2025.102446. Epub 2025 May 24.
This study evaluates the effects of a modest reduction in back optic zone diameter (BOZD) in orthokeratology (ortho-k) lenses on axial elongation and visual performance. The goal is to determine whether this adjustment enhances myopia control in children with rapid progression and suboptimal outcomes, while maintaining visual quality and exploring the underlying mechanisms.
This retrospective study analyzed data from 109 myopic children undergoing ortho-k fitting over two years. The continued group wore traditional 6.0 mm BOZD lenses, while the switched group wore 6.0 mm lenses in the first year and transitioned to 5.8 mm BOZD lenses in the second year. The changes of Axial length (AL) elongation and corneal topography parameters, including treatment zone (TZ) size, cumulative relative corneal refractive power within a 4.80 mm diameter (Sum4.8), TZ decentration, and percentage of defocus zone within the pupil area (PDZP).
In the continued and switched groups, the baseline age was 9.92 ± 2.19 and 9.38 ± 1.58 years, respectively. During the second year, the switched group exhibited a significantly reduced AL elongation compared to the continued group (0.17 ± 0.24 mm vs 0.28 ± 0.17 mm, p = 0.02). Additionally, Sum4.8 was significantly elevated in the continued group. However, there wasno significant differences in TZ size and decentration, or PDZP between the two groups, indicating that the 0.2 mm reduction in BOZD may not be sufficient to influence these parameters.
The transition to a BOZD of 5.8 mm improved myopia management by mitigating AL elongation without producing visual problems, possibly attributable to an augmented peripheral myopic defocus. This study offers empirical support for the clinical advantages of decreasing BOZD in ortho-k for pediatric patients with suboptimal myopia control.
本研究评估在角膜塑形术(ortho-k)镜片中适度减小后光学区直径(BOZD)对眼轴伸长和视觉性能的影响。目的是确定这种调整是否能在维持视觉质量并探索潜在机制的同时,增强近视进展迅速且效果欠佳的儿童的近视控制效果。
这项回顾性研究分析了两年内109名接受ortho-k配镜的近视儿童的数据。持续组佩戴传统的6.0毫米BOZD镜片,而转换组在第一年佩戴6.0毫米镜片,并在第二年过渡到5.8毫米BOZD镜片。测量眼轴长度(AL)伸长以及角膜地形图参数的变化,包括治疗区(TZ)大小、直径4.80毫米范围内的累积相对角膜屈光力(Sum4.8)、TZ偏心度以及瞳孔区域内散焦区百分比(PDZP)。
在持续组和转换组中,基线年龄分别为9.92±2.19岁和9.38±1.58岁。在第二年,转换组的AL伸长相比持续组显著降低(0.17±0.24毫米对0.28±0.17毫米,p = 0.02)。此外,持续组的Sum4.8显著升高。然而,两组之间在TZ大小、偏心度或PDZP方面没有显著差异,这表明BOZD减小0.2毫米可能不足以影响这些参数。
向5.8毫米BOZD的转变通过减轻AL伸长改善了近视管理,且未产生视觉问题,这可能归因于周边近视性离焦增加。本研究为在ortho-k中减小BOZD对近视控制欠佳的儿科患者的临床优势提供了实证支持。