Guo Songhai, Sun Bin, Wang Xinghe, Zhou Chunyan, Li Weihua, Sun Jia, Wang Liwei, Fan Conghai
College of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
Sci Rep. 2025 May 25;15(1):18146. doi: 10.1038/s41598-025-01892-5.
To investigate the effect of intravenous lidocaine on postoperative fatigue syndrome (POFS) in laparoscopic radical colorectal cancer surgery patients, a randomized controlled trial enrolled 86 patients aged over 18 with preoperative Christensen score ≤ 4 at Xuzhou Central Hospital from September 2023 to June 2024. The lidocaine group (group L) received an intravenous infusion of 1.5 mg·kg of lidocaine for 15 min, 30 min prior to anesthetic induction, followed by sustained infusion at 1.5 mg·kg·h until surgical closure. The control group (group C) received an equal volume of normal saline in the same manner. Compared with the group C, the time-weighted average (TWA) of Christensen score in the group L decreased by 0.42 (95% CI, 0.12 ~ 0.73, P < 0.05). Compared with the group C, the VAS at 1,3 and 5 days after surgery in the group L were lower (P < 0.05), the levels of IL-6 and TNF-α immediately after surgery and 24 h after surgery were lower (P < 0.05), and the time to first flatus and defecation was shorter (P < 0.05). No significant differences between the two groups in extubation time, PACU stay duration, incidence of postoperative nausea and vomiting (PONV), or length of postoperative hospital stay (P > 0.05). Results indicate that intravenous lidocaine effectively improved POFS in patients undergoing laparoscopic radical resection of colorectal cancer, which might be achieved by inhibiting the postoperative inflammatory response and reducing postoperative pain.
为研究静脉注射利多卡因对腹腔镜根治性结直肠癌手术患者术后疲劳综合征（POFS）的影响，一项随机对照试验于2023年9月至2024年6月在徐州中心医院纳入了86例年龄超过18岁、术前克里斯滕森评分≤4分的患者。利多卡因组（L组）在麻醉诱导前30分钟静脉输注1.5mg·kg利多卡因15分钟，随后以1.5mg·kg·h持续输注直至手术结束。对照组（C组）以相同方式输注等量生理盐水。与C组相比，L组克里斯滕森评分的时间加权平均值（TWA）降低了0.42（95%CI，0.12～0.73，P＜0.05）。与C组相比，L组术后1天、3天和5天的视觉模拟评分（VAS）更低（P＜0.05），术后即刻及术后24小时的白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平更低（P＜0.05），首次排气和排便时间更短（P＜0.05）。两组在拔管时间、麻醉后恢复室（PACU）停留时间、术后恶心呕吐（PONV）发生率或术后住院时间方面无显著差异（P＞0.05）。结果表明，静脉注射利多卡因可有效改善腹腔镜根治性结直肠癌手术患者的POFS，这可能是通过抑制术后炎症反应和减轻术后疼痛来实现的。
