Machado Pedro, Pimenta Sara, Oliveiros Bárbara, Ferreira José Pedro, Martins Raul A, Cruz Joana
Center for Innovative Care and Health Technology (ciTechCare), School of Health Sciences of the Polytechnic of Leiria, 2411-901 Leiria, Portugal.
University of Coimbra, Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal.
Cancers (Basel). 2021 Oct 3;13(19):4975. doi: 10.3390/cancers13194975.
Surgical treatment affects health-related quality of life (HRQoL) and increases fatigue symptoms in patients with lung cancer (LC) and colorectal cancer (CRC). We aimed to systematically review the effect of exercise training on HRQoL and fatigue after LC and CRC surgery. Randomized controlled trials published before 21 March 2021, were searched in PubMed, Scopus, Web of Science, SPORTDiscus and PEDro. Eligible trials compared the effect of exercise interventions initiated preoperatively or in the first 3 months after surgery versus usual care on postoperative HRQoL and fatigue. Standardized mean differences (SMD) were pooled using random-effects models. Twelve studies with a total of 777 patients were included. In LC patients (10 studies, n = 651), exercise training in general led to a moderate improvement in the physical domain of HRQoL (0.68: 95% CI: [0.47; 0.89]) and a small reduction in fatigue levels after surgery (SMD = 0.28: 95% CI: [0.02; 0.53]), while no effects were found in other HRQoL domains. In CRC (two studies, = 126), exercise training showed no effects on HRQoL and fatigue after surgery. Exercise training is an effective intervention to improve physical function and fatigue after LC surgery. Further studies are necessary to clarify the effects of exercise on HRQoL and fatigue after CRC surgery.
手术治疗会影响肺癌（LC）和结直肠癌（CRC）患者的健康相关生活质量（HRQoL）并增加疲劳症状。我们旨在系统评价运动训练对LC和CRC手术后HRQoL及疲劳的影响。在PubMed、Scopus、Web of Science、SPORTDiscus和PEDro中检索了2021年3月21日前发表的随机对照试验。符合条件的试验比较了术前或术后前3个月开始的运动干预与常规护理对术后HRQoL和疲劳的影响。使用随机效应模型汇总标准化均数差（SMD）。纳入了12项研究，共777例患者。在LC患者中（10项研究，n = 651），一般来说运动训练导致HRQoL身体领域有中度改善（0.68：95%CI：[0.47；0.89]），术后疲劳水平有小幅降低（SMD = 0.28：95%CI：[0.02；0.53]），而在其他HRQoL领域未发现影响。在CRC患者中（两项研究，n = 126），运动训练对术后HRQoL和疲劳无影响。运动训练是改善LC手术后身体功能和疲劳的有效干预措施。需要进一步研究以阐明运动对CRC手术后HRQoL和疲劳的影响。
