Di Filippo Leonardo Delello, Duarte Jonatas Lobato, de Almeida Allana Carolina Leme, Tashiro Felipe Mota, Peleje Isabel Rheinfranck, Chorilli Marlus
Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University "Júlio de Mesquita Filho", Araraquara, Brazil.
Nanomedicine (Lond). 2025 Jun;20(12):1441-1459. doi: 10.1080/17435889.2025.2506347. Epub 2025 May 25.
Inflammatory skin diseases are chronic conditions that significantly affect patients' skin health and quality of life. Traditional treatments, including systemic immunosuppressants and topical therapies, often face limitations such as low efficacy, inadequate skin penetration, and severe side effects. Nanotechnology has emerged as a promising solution to tackle these challenges by providing innovative drug delivery systems that not only enhance therapeutic precision but also reduce systemic exposure. This review highlights the technological innovations and pre-clinical potential of nanotechnology-based therapies in managing inflammatory skin diseases, emphasizing their advantages over conventional treatments and their ability to overcome existing therapeutic limitations. Drug delivery nanosystems like lipid, polymeric, and metallic nanocarriers can be designed to penetrate the skin barrier and deliver drugs directly to the affected tissues. These nanocarriers improve drug stability, bioavailability, and retention in target areas while minimizing adverse effects. Furthermore, nanoparticles can be functionalized with bioadhesive molecules (e.g. hyaluronic acid) to achieve targeted and sustained drug release. In preclinical studies, such advanced formulations have demonstrated the potential to modulate immune responses and reduce inflammation by delivering therapeutics in a controlled and localized manner.
炎症性皮肤病是严重影响患者皮肤健康和生活质量的慢性疾病。传统治疗方法，包括全身免疫抑制剂和局部治疗，常常面临疗效低、皮肤渗透性不足以及严重副作用等局限性。纳米技术作为一种有前景的解决方案应运而生，它通过提供创新的药物递送系统来应对这些挑战，这种系统不仅能提高治疗精准度，还能减少全身暴露。本综述重点介绍了基于纳米技术的疗法在治疗炎症性皮肤病方面的技术创新和临床前潜力，强调了它们相对于传统治疗方法的优势以及克服现有治疗局限性的能力。脂质、聚合物和金属纳米载体等药物递送纳米系统可设计用于穿透皮肤屏障并将药物直接递送至受影响的组织。这些纳米载体可提高药物稳定性、生物利用度，并在靶区域保持药物，同时将不良反应降至最低。此外，纳米颗粒可用生物粘附分子（如透明质酸）进行功能化修饰，以实现靶向和持续的药物释放。在临床前研究中，此类先进制剂已显示出通过以可控和局部的方式递送治疗药物来调节免疫反应和减轻炎症的潜力。
