Mosiichuk Nadiia, Enggren Gabriela, Da Silva Zita Lopes, Morén Anna Karin, Hansson Henri, Engblom Johan, Ruzgas Tautgirdas
Department of Biomedical Science, Faculty of Health and Society, Malmö University, Malmö, Sweden.
Biofilms Research Centre for Biointerfaces, Malmö University, Malmö, Sweden.
J Antimicrob Chemother. 2025 Jul 1;80(7):1947-1950. doi: 10.1093/jac/dkaf153.
Staphylococcus aureus and Staphylococcus epidermidis normally coexist on the skin of healthy individuals. Their ratio and pathogenicity, however, change with different skin diseases and thus, the ability to control bacterial growth on the skin is important. Propylene glycol (PG), a widely used component in topical formulations, has been proved to have antimicrobial activity.
To investigate the concentration-dependent antimicrobial properties of PG against S. aureus and S. epidermidis skin isolates in mono- and co-culture at neutral (pH 7.4) and mildly acidic (pH 5) conditions.
The minimum inhibitory concentration of PG was 12.5% at both pH 5 and pH 7.4 for the selected bacterial strains. The viability of S. aureus exposed to 12.5% PG was lower at pH 5 than at pH 7.4, and post-treatment regrowth of S. aureus occurred slowly at acidic pH. When both bacterial strains were incubated in media containing 12.5% PG at pH 5 for 48 hours, S. epidermidis retained significantly higher viability, while at pH 7.4, the results were opposite.
Under the acidic conditions of healthy skin, pathogenic S. aureus is more suppressed by 12.5% PG than commensal S. epidermidis.
金黄色葡萄球菌和表皮葡萄球菌通常共存于健康个体的皮肤上。然而，它们的比例和致病性会因不同的皮肤疾病而改变，因此，控制皮肤细菌生长的能力很重要。丙二醇（PG）是局部制剂中广泛使用的成分，已被证明具有抗菌活性。
研究在中性（pH 7.4）和轻度酸性（pH 5）条件下，PG对单培养和共培养的金黄色葡萄球菌和表皮葡萄球菌皮肤分离株的浓度依赖性抗菌特性。
对于所选细菌菌株，PG在pH 5和pH 7.4时的最低抑菌浓度均为12.5%。暴露于12.5% PG的金黄色葡萄球菌在pH 5时的活力低于pH 7.4时，且在酸性pH下，金黄色葡萄球菌处理后的再生长缓慢。当两种细菌菌株在pH 5含12.5% PG的培养基中孵育48小时时，表皮葡萄球菌的活力显著更高，而在pH 7.4时，结果相反。
在健康皮肤的酸性条件下，12.5%的PG对致病性金黄色葡萄球菌的抑制作用比对共生表皮葡萄球菌的抑制作用更强。
