Soverina Soledad, Gilliland Haleigh N, Olive Andrew J
Department of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
Virulence. 2025 Dec;16(1):2508813. doi: 10.1080/21505594.2025.2508813. Epub 2025 May 26.
Non-tuberculous mycobacteria (NTM), such as (Mab) are an increasing cause of human disease. While the majority of immunocompetent hosts control Mab infections, the robust survival of Mab within the environment has shaped survival in human cells to help drive persistence and cause inflammatory damage in susceptible individuals. With high intrinsic resistance to antibiotics, there is an important need to fully understand how Mab causes infection, define protective host pathways that control disease, and develop new strategies to treat those at high risk. This review will examine the existing literature related to host-Mab interactions with a focus on virulence, the host response, and therapy development. The goal is to highlight key gaps in our understanding and describe novel approaches to encourage new research avenues that better define the pathogenesis and host response against this increasingly important human pathogen.
非结核分枝杆菌（NTM），如脓肿分枝杆菌（Mab），正日益成为人类疾病的一个病因。虽然大多数免疫功能正常的宿主能够控制Mab感染，但Mab在环境中的强大生存能力使其在人类细胞中得以存活，从而促使其持续存在并在易感个体中造成炎症损伤。由于Mab对抗生素具有高度固有耐药性，因此迫切需要全面了解Mab如何引起感染、确定控制疾病的保护性宿主途径，并开发新的策略来治疗高危人群。本综述将审视与宿主-Mab相互作用相关的现有文献，重点关注毒力、宿主反应和治疗方法的开发。目的是突出我们理解上的关键差距，并描述新方法，以鼓励开展新的研究途径，从而更好地界定针对这种日益重要的人类病原体的发病机制和宿主反应。
