Liao Changpin, Lu Zhen, Pan Guiying, Ye Jing, Nong Shengde, Nordin Rusli, Liang Jiancheng, Fazel Muhammad Fattah, Baharin Nurul Hana Zainal
Department of Neurosurgery, Baise People's Hospital, Baise, Guangxi, China.
Department of Oncology Radiotherapy, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Front Neurosci. 2025 May 9;19:1526910. doi: 10.3389/fnins.2025.1526910. eCollection 2025.
To investigate the efficacy of diffusion tensor imaging (DTI) in assessing the motor impairment resulting from minor basal ganglia hemorrhage post-stereotactic surgery.
A total of 104 patients with minor basal ganglia hemorrhages (hematoma volume ≤15 ml) underwent DTI within 48 h and 1 month post-treatment. Patients were divided into two groups: 42 in the experimental group, receiving stereotactic surgery and medication, and 62 in the control group, receiving medication alone. The corticospinal tract (CST) of the posterior limb of the internal capsule was the region of interest (ROI) for assessing mean FA values on both sides. Fugl-Meyer motor function (FMF) scores were recorded within 48 h and 1 month post-treatment, and Modified Rankin Scale (MRS) scores at 6 months.
After 1 month of treatment, the FA values and FMF scores for the affected side of patients in the experimental group were 0.34 ± 0.17 and 67.84 ± 4.72, respectively, significantly surpassing those of the control group, which were 0.21 ± 0.06 and 45.38 ± 2.25 ( < 0.05). After 6 months of treatment, the experimental group exhibited MRS scores of 10 cases (23.81%) at grade 0, 12 cases (28.57%) at grade 1, 16 cases (38.10%) at grade 2, 2 cases (4.76%) at grade 3, 2 cases (4.76%) at grade 4, and 0 cases at grade 5. In contrast, the control group demonstrated 8 cases (12.90%) at grade 0, 12 cases (19.35%) at grade 1, 18 cases (29.03%) at grade 2, 15 cases (24.19%) at grade 3, 6 cases (9.68%) at grade 4, and 3 cases (4.84%) at grade 5. There are 18 cases (29.03%) in grade 2, 15 cases (24.19%) in grade 3, 6 cases (9.68%) in grade 4, and 3 cases (4.84%) in grade 5 within the control group. The experimental group showed a significantly better MRS score compared to the control group ( < 0.05).
DTI can accurately evaluate the structural integrity of the CST in patients with minor basal ganglia hemorrhages following stereotactic surgery, particularly regarding the CST pathways involved in motor control, providing valuable guidance for clinical treatment.
探讨弥散张量成像（DTI）在评估立体定向手术后基底节区少量出血所致运动功能障碍中的应用价值。
选取104例基底节区少量出血（血肿体积≤15 ml）患者，分别于治疗后48 h内及1个月行DTI检查。将患者分为两组：实验组42例，接受立体定向手术及药物治疗；对照组62例，单纯接受药物治疗。以内囊后肢皮质脊髓束（CST）为感兴趣区（ROI），评估双侧平均FA值。分别于治疗后48 h内及1个月记录Fugl-Meyer运动功能（FMF）评分，6个月时记录改良Rankin量表（MRS）评分。
治疗1个月后，实验组患者患侧FA值及FMF评分分别为0.34±0.17和67.84±4.72，显著高于对照组的0.21±0.06和45.38±2.25（P<0.05）。治疗6个月后，实验组MRS评分0级10例（23.81%），1级12例（28.57%），2级16例（38.10%），3级2例（4.76%），4级2例（4.76%），5级0例；对照组MRS评分0级8例（12.90%），1级12例（19.35%），2级18例（29.03%），3级15例（24.19%），4级6例（9.68%），5级3例（4.84%）。实验组MRS评分明显优于对照组（P<0.05）。
DTI能够准确评估立体定向手术后基底节区少量出血患者CST的结构完整性，尤其是参与运动控制的CST通路，为临床治疗提供有价值的指导。
