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[单碘乙酸给药诱导实验性视网膜病变时兔视觉系统中的振荡诱发电位]

[Oscillatory evoked potentials in the rabbit visual system during experimental retinal pathology induced by administration of monoiodoacetic acid].

作者信息

Gasanov G G, Gadzhieva N A, Rzaeva N M, Dmitrenko A I, Kulieva F B

出版信息

Biull Eksp Biol Med. 1985 Sep;100(9):289-92.

PMID:4041592
Abstract

ERG and EP of the visual cortex (VC) and superior colliculus (SC) were investigated under experimental dystrophy of the retina induced by intravenous injection of monoiodoacetic acid in different doses. The relative resistance of the VC to the derangement of retinal function was established. It was manifested by less marked suppression of its EP as compared with ERG. Taking into consideration the selective projection to the SC of the rod system that was damaged to a greater degree under pathology in question, it is suggested that functional suppression of the SC might facilitate the conduction of visual information through the main retino-geniculo-cortical canal. This might be one of the factors of VC resistance to the impairment of retinal function. This assumption was confirmed in experiments with SC electrocoagulation in which one could observe the facilitation of EP formation of the contralateral VC.

摘要

在通过静脉注射不同剂量的一碘乙酸诱导视网膜实验性营养不良的情况下,对视皮层(VC)和上丘(SC)的视网膜电图(ERG)和视觉诱发电位(EP)进行了研究。确定了视皮层对视网膜功能紊乱的相对抗性。与ERG相比,其EP的抑制不太明显,这体现了这种抗性。考虑到在所讨论的病理情况下受损程度更大的视杆系统选择性投射至上丘,有人提出上丘的功能抑制可能有助于视觉信息通过主要的视网膜 - 膝状体 - 皮层通路传导。这可能是视皮层对视网膜功能损害具有抗性的因素之一。在对上丘进行电凝的实验中证实了这一假设,在该实验中可以观察到对侧视皮层EP形成的促进作用。

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