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在以人类为目标的锥蝽中发现的天然宿主：萨尔瓦多全国病媒监测结果

Natural Reservoir of Found in Triatomines Targeting Humans: Results from Nation-wide Vector Surveillance in El Salvador.

作者信息

Michimuko-Nagahara Yu, Nakagama Yu, Rodriguez Marvin Stanley, Kaku Natsuko, Nitahara Yuko, Candray Katherine, Tshibangu-Kabamba Evariste, Hamano Shinjiro, Hirayama Kenji, Kaneko Akira, Nakajima-Shimada Junko, Onizuka Yoko, Romero José Eduardo, Palacios José Ricardo, Arias Carmen Elena, Mejía William, Alvarenga Ricardo Cardona, Kido Yasutoshi

机构信息

Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

Department of Parasitology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

出版信息

JMA J. 2025 Apr 28;8(2):432-443. doi: 10.31662/jmaj.2024-0182. Epub 2025 Mar 28.

DOI:10.31662/jmaj.2024-0182
PMID:40415989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12095551/
Abstract

INTRODUCTION

Chagas disease is one of the most critical of the neglected tropical diseases in Latin America where it poses a serious public health issue. However, the current burden of vectorial transmission from natural reservoirs to humans is unclear. This study aimed to clarify the active mode of transmission to humans disentangled from the feeding pattern of () infected by ().

METHODS

A total of 1,376 specimens were collected across the 14 departments of El Salvador. From these specimens, 135 midgut samples from 37 households in eight departments were positive for (n = 135/1,376; 9.8% [95% confidential interval (CI): 8.35%-11.5%]). Using a universal vertebrate primer, vertebrate blood sources were positively identified by next-generation sequence analysis of deoxyribonucleic acid (DNA) extracted from the midgut contents of

RESULTS

A total of 13 vertebrates were detected as blood sources; humans, and five domestic, three synanthropic, and four sylvatic species. Triatomines identified as having fed on human blood accounted for approximately 67% (n = 90/135 [95% CI: 58.3%-74.1%]) of the samples analyzed.

CONCLUSIONS

In this study, a holistic understanding of the feeding patterns of -positive in El Salvador is dated. The detection of human DNA in the midgut contents of indicated the possibility of active vectorial transmission to humans.

摘要

引言

恰加斯病是拉丁美洲最严重的被忽视热带病之一，构成了严重的公共卫生问题。然而，目前从天然宿主向人类进行病媒传播的负担尚不清楚。本研究旨在阐明与感染锥蝽的吸血模式无关的向人类的主动传播方式。

方法

在萨尔瓦多的14个省共采集了1376份锥蝽标本。从这些标本中，来自8个省37户家庭的135份中肠样本检测出克氏锥虫呈阳性（n = 135/1376；9.8%[95%置信区间（CI）：8.35%-11.5%]）。使用通用脊椎动物引物，通过对从中肠内容物中提取的脱氧核糖核酸（DNA）进行下一代序列分析，阳性鉴定脊椎动物血液来源。

结果

共检测到13种脊椎动物为血液来源；包括人类，以及5种家养、3种伴人、4种野生脊椎动物物种。被鉴定为吸食人血的锥蝽约占所分析样本的67%（n = 90/135[95% CI：58.3%-74.1%]）。

结论

在本研究中，对萨尔瓦多克氏锥虫阳性锥蝽的吸血模式有了全面了解。在锥蝽中肠内容物中检测到人类DNA表明存在向人类的主动病媒传播可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/d7b1bdc912c5/2433-3298-8-2-0432-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/1b6e0ed8fd10/2433-3298-8-2-0432-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/e7ffb7fceb3a/2433-3298-8-2-0432-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/830baed3800a/2433-3298-8-2-0432-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/495906f3f3e0/2433-3298-8-2-0432-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/3bae935183a6/2433-3298-8-2-0432-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/d7b1bdc912c5/2433-3298-8-2-0432-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/1b6e0ed8fd10/2433-3298-8-2-0432-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/e7ffb7fceb3a/2433-3298-8-2-0432-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/830baed3800a/2433-3298-8-2-0432-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/495906f3f3e0/2433-3298-8-2-0432-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/3bae935183a6/2433-3298-8-2-0432-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c95/12095551/d7b1bdc912c5/2433-3298-8-2-0432-g006.jpg

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