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钙依赖性调节蛋白(CDR)在流感病毒抑制3',5'-环磷酸腺苷磷酸二酯酶中的作用。I. 从鸡胚中分离纯化CDR及依赖CDR的3',5'-环磷酸腺苷磷酸二酯酶

Role of calcium dependent regulator protein (CDR) in inhibition of 3',5'-c AMP-phosphodiesterase by influenza virus. I. Isolation and purification of CDR and CDR-dependent 3',5'-c' AMP-phosphodiesterase from chick embryos.

作者信息

Krizanová O, Soláriková L, Hána L

出版信息

Acta Virol. 1979 Jul;23(4):295-302.

PMID:40416
Abstract

Calcium-dependent regulator protein (CDR) and CDR-dependent 3',5'-c AMP-phosphodiesterase were isolated and partially purified from 12-day chick embryos. Some basic properties of the preparations obtained were described. Native (infectious) but not noninfectious (heat-inactivated) influenza virus in the presence of CDR and ATP reduced the activity of CDR-dependent phosphodiesterase.

摘要

从12日龄鸡胚中分离并部分纯化了钙依赖性调节蛋白(CDR)和CDR依赖性3',5'-环磷酸腺苷磷酸二酯酶。描述了所获得制剂的一些基本特性。在CDR和ATP存在下,天然(有感染性)而非无感染性(热灭活)流感病毒降低了CDR依赖性磷酸二酯酶的活性。

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