Bharti Vineet, Joshi Mrinal, Saini Neha
Physical Medicine and Rehabilitation, Employees State Insurance Corporation (ESIC) Medical College and Hospital, Faridabad, IND.
Physical Medicine and Rehabilitation, Sawai Man Singh (SMS) Medical College, Jaipur, IND.
Cureus. 2025 Apr 23;17(4):e82865. doi: 10.7759/cureus.82865. eCollection 2025 Apr.
Following spinal cord injury, neurogenic detrusor overactivity elevates detrusor leak point pressure, endangering renal function. This research examined oxybutynin's effects on detrusor leak point pressure and urodynamic parameters in 30 individuals with spinal cord injury and neurogenic detrusor overactivity, emphasizing variations across subgroups. Patients were given 5 mg of oxybutynin each day for a week, with urodynamic assessments conducted pre- and post-treatment. Decreases in detrusor leak point pressure were noted, especially among those with detrusor hyperreflexia combined with detrusor sphincter dyssynergia, cervical-level injuries, and injuries exceeding six months. Improvements in bladder compliance and capacity occurred universally, yet detrusor leak point pressure reductions differed by subgroup. Oxybutynin proves useful in reducing detrusor leak point pressure in vulnerable spinal cord injury patients, promoting its application in customized neurogenic detrusor overactivity care.
脊髓损伤后，神经源性逼尿肌过度活动会升高逼尿肌漏点压力，危及肾功能。本研究调查了奥昔布宁对30例脊髓损伤合并神经源性逼尿肌过度活动患者的逼尿肌漏点压力及尿动力学参数的影响，重点关注各亚组之间的差异。患者每天服用5毫克奥昔布宁，持续一周，治疗前后均进行尿动力学评估。结果发现逼尿肌漏点压力有所降低，尤其是在那些逼尿肌反射亢进合并逼尿肌括约肌协同失调、颈髓水平损伤以及损伤超过六个月的患者中。膀胱顺应性和容量普遍有所改善，但逼尿肌漏点压力的降低因亚组而异。奥昔布宁被证明有助于降低易患脊髓损伤患者的逼尿肌漏点压力，促进其在个性化神经源性逼尿肌过度活动护理中的应用。
