Freixa-Benavente Andrea, Dolader Paola, Gran Ferran, Betrián-Blasco Pedro
Unitat Hemodinàmica Pediàtrica, Cardiologia Pediàtrica, Hospital Universitari Vall d'Hebron, Barcelona, España Unitat Hemodinàmica Pediàtrica Cardiologia Pediàtrica Hospital Universitari Vall d'Hebron Barcelona España.
Unitat de Insuficiència Cardíaca i Trasplantament Cardíac Pediàtrics, Hospital Universitari Vall d'Hebron, Barcelona, España Unitat de Insuficiència Cardíaca i Trasplantament Cardíac Pediàtrics Hospital Universitari Vall d'Hebron Barcelona España.
REC Interv Cardiol. 2023 Dec 19;6(2):97-105. doi: 10.24875/RECIC.M23000417. eCollection 2024 Apr-Jun.
Although cardiac catheterization (CC) has become a routine practice in pediatric heart transplantation (HT), there is still a shortage of widely used protocols and strong evidence on the number of procedures required and their impact on HT outcomes, as well as the need for further CC. This study aimed to analyze CC activity in pediatric HT recipients in a tertiary center and describe risk factors for a higher number of post-HT procedures.
This retrospective study obtained data from medical reports and image files. The sample was composed of patients with cardiomyopathies and congenital heart diseases (CHD). Risk factor analysis for CCs was conducted with linear regression and the ANOVA test.
The sample included 61 children (36.07% with CHD). The CHD group had a higher mean number of CCs prior to HT. The most frequent activities prior to HT were diagnostic catheterizations, followed by endomyocardial biopsies for cardiomyopathies and aortopulmonary collaterals in CHD patients. There were 389 post-HT CCs (608 procedures). Most CCs were performed for rejection surveillance, accounting for 92.75% of procedures. The univentricular CHD subgroup was associated with a higher number of CC after HT ( = .03).
Despite long life expectancy, pediatric HT recipients have substantial morbidity due to these procedures. Therefore, it is necessary to establish protocols for follow-up and rejection surveillance to minimize the interventions required by these patients.
尽管心导管检查(CC)已成为小儿心脏移植(HT)中的常规操作,但在所需操作的数量及其对心脏移植结果的影响,以及进一步进行心导管检查的必要性方面,仍缺乏广泛应用的方案和有力证据。本研究旨在分析一家三级中心小儿心脏移植受者的心导管检查情况,并描述心脏移植后操作次数较多的危险因素。
这项回顾性研究从医疗报告和影像文件中获取数据。样本由患有心肌病和先天性心脏病(CHD)的患者组成。采用线性回归和方差分析对心导管检查的危险因素进行分析。
样本包括61名儿童(36.07%患有先天性心脏病)。先天性心脏病组在心脏移植前的心导管检查平均次数较高。心脏移植前最常见的心导管检查操作是诊断性导管插入术,其次是针对心肌病的心肌内膜活检以及先天性心脏病患者的主肺动脉侧支血管检查。心脏移植后进行了389次心导管检查(共608项操作)。大多数心导管检查是为了进行排斥反应监测,占操作总数的92.75%。单心室先天性心脏病亚组与心脏移植后较高的心导管检查次数相关(P = 0.03)。
尽管小儿心脏移植受者预期寿命较长,但由于这些操作,他们仍有较高的发病率。因此,有必要制定随访和排斥反应监测方案,以尽量减少这些患者所需的干预措施。