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一例伴有类癌综合征的转移性胰腺神经内分泌肿瘤的跌宕历程

A Tumultuous Journey of Metastatic Pancreatic Neuroendocrine Tumor with Carcinoid Syndrome.

作者信息

Giri Somdatta, Kamalanathan Sadishkumar, Raja Kalayarasan, Pandit Nandini, Naik Dukhabandhu, Sahoo Jayaprakash

机构信息

Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Department of Surgical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

出版信息

J ASEAN Fed Endocr Soc. 2025 May;40(1):112-116. doi: 10.15605/jafes.040.01.04. Epub 2025 Apr 20.

Abstract

A 25-year-old woman presented with metastatic pancreatic neuroendocrine tumor with carcinoid syndrome. She was refractory to octreotide and did not respond well to chemotherapy. Although surgical debulking remains the primary approach for managing these tumours, it entails inherent risks, including potentially exacerbating carcinoid syndrome. We strategically delivered the one Peptide Receptor Radionuclide Therapy cycle before tumor debulking, a decision that yielded a remarkable response, stabilizing her condition.

摘要

一名25岁女性因转移性胰腺神经内分泌肿瘤伴类癌综合征就诊。她对奥曲肽耐药,化疗效果也不佳。尽管手术减瘤仍是治疗这些肿瘤的主要方法,但该方法存在固有风险,包括可能加剧类癌综合征。我们在肿瘤减瘤前有策略地进行了一个周期的肽受体放射性核素治疗,这一决定产生了显著效果,稳定了她的病情。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0991/12102652/3b0109bf1fc3/JAFES-40-1-112-g001.jpg

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