沉默信息调节因子1：糖皮质激素抵抗性疾病的潜在靶点。
SIRT1: potential target in glucocorticoid-resistant diseases.
作者信息
Xie Jun, Che Siyi, Liu Jiao, Long Xiaoru
机构信息
Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
出版信息
Front Immunol. 2025 May 9;16:1514745. doi: 10.3389/fimmu.2025.1514745. eCollection 2025.
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases. In steroid-resistant airway inflammatory diseases, glucocorticoid receptor (GR) expression is reduced, and impaired GR nuclear translocation is closely related to glucocorticoid resistance. Histone deacetylase SIRT1 regulates steroid hormone receptor activity and interacts with the androgen receptor and GR. In some glucocorticoid-resistant diseases, SIRT1 expression is reduced. Here, we review recent advances in the role of SIRT1 in regulating glucocorticoid signaling. First, we describe the structure, tissue expression, and subcellular localization of SIRT1. We also discuss the molecular mechanisms by which SIRT1 regulates glucocorticoid activity and its association with GR, as well as the mechanisms and roles of SIRT1 in several common glucocorticoid-resistant diseases. SIRT1 may serve as a potential therapeutic target, providing an opportunity for the treatment of glucocorticoid-resistant diseases.
糖皮质激素抵抗是临床实践中一个具有挑战性的问题。提高糖皮质激素敏感性和降低抵抗性在某些疾病的治疗中很重要。在激素抵抗性气道炎性疾病中，糖皮质激素受体（GR）表达降低，GR核转位受损与糖皮质激素抵抗密切相关。组蛋白去乙酰化酶SIRT1调节甾体激素受体活性，并与雄激素受体和GR相互作用。在一些糖皮质激素抵抗性疾病中，SIRT1表达降低。在此，我们综述SIRT1在调节糖皮质激素信号传导中作用的最新进展。首先，我们描述SIRT1的结构、组织表达和亚细胞定位。我们还讨论SIRT1调节糖皮质激素活性的分子机制及其与GR的关联，以及SIRT1在几种常见糖皮质激素抵抗性疾病中的机制和作用。SIRT1可能作为一个潜在的治疗靶点，为糖皮质激素抵抗性疾病的治疗提供机会。
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