Yang Caide, Bao Jinlian, Li Dengke
Department of Integrated Traditional Chinese and Western Medicine, Donggang Hospital, The First Hospital of Lanzhou University, Lanzhou, 730020, China.
Department of Pharmacy, Donggang Hospital, The First Hospital of Lanzhou University, Lanzhou, 730020, China.
Open Life Sci. 2025 May 20;20(1):20221060. doi: 10.1515/biol-2022-1060. eCollection 2025.
This study aims to explore changes in peripheral blood T-lymphocyte subsets in colorectal cancer (CRC) patients before and after acupoint catgut embedding (ACE) acupuncture observation. Eighty CRC surgical patients who visited from April 2017 to May 2022 were selected as study samples using the convenience sampling method. Patients were randomly divided into a control group ( = 40, receiving conventional chemotherapy) and an observation group ( = 40, receiving 4 weeks of additional ACE acupuncture). The observation group showed higher rates of complete and partial remission compared to the control, though the difference was not statistically significant ( > 0.05). The observation group experienced less reduction in CD, CD T lymphocytes, and natural killer cells during chemotherapy. Compared with the control group, the percentage of CD and CD T cells in the observation group significantly increased after the intervention, while CD T-cell levels decreased. The CD/CD ratio was at a higher level, and the discrepancy was statistically obvious ( < 0.05). Acupuncture therapy can maintain the normal distribution of peripheral blood T-lymphocyte subpopulations during chemotherapy in patients with CRC, thus better maintaining the immune status of patients.
本研究旨在探讨穴位埋线针刺观察前后结直肠癌（CRC）患者外周血T淋巴细胞亚群的变化。采用便利抽样法，选取2017年4月至2022年5月就诊的80例CRC手术患者作为研究样本。将患者随机分为对照组（n = 40，接受常规化疗）和观察组（n = 40，额外接受4周穴位埋线针刺）。与对照组相比，观察组的完全缓解和部分缓解率更高，尽管差异无统计学意义（P>0.05）。观察组在化疗期间CD、CD T淋巴细胞和自然杀伤细胞的减少较少。与对照组相比，观察组干预后CD和CD T细胞的百分比显著增加，而CD T细胞水平下降。CD/CD比值处于较高水平，差异具有统计学意义（P<0.05）。针刺疗法可维持CRC患者化疗期间外周血T淋巴细胞亚群的正常分布，从而更好地维持患者的免疫状态。
