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阿尔茨海默病患者颈深部静脉淋巴管吻合术的围手术期护理及恢复结果:一例报告

Perioperative care and recovery outcome of deep jugular venous lymphatic anastomosis in Alzheimer's disease: A case report.

作者信息

Chen Li, Peng Lang, Guo Xiaojing, Liu Wumei, Shi Qian, Zhao Meiying, Wang Feiyun, Li Mingzi, Li Chunhong, Zhang Yaqin

机构信息

Department of Geriatrics, Zhengzhou Central Hospital Yuxin Geriatric Hospital, Zhengzhou, China.

School of Nursing, Peking University, Beijing, China.

出版信息

J Alzheimers Dis Rep. 2025 May 23;9:25424823251342487. doi: 10.1177/25424823251342487. eCollection 2025 Jan-Dec.

DOI:10.1177/25424823251342487
PMID:40417068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12102557/
Abstract

This case reports a 74-year-old female from eastern China presented with memory loss, dyscalculia, language disorders, diagnosed with Alzheimer's disease and underwent deep cervical venous lymphatic anastomosis. After rigorous preoperative evaluation, surgical treatment, and postoperative care, the patient had no postoperative care-related complications and showed obvious improvement in her language and self-care skills. The patient's Mini-Mental State Examination score improved three months after surgery compared to the preoperative period (5 versus 0). This case illustrates the potential of related surgery in the treatment of Alzheimer's disease and emphasizes that proper medical and nursing care are essential for better recovery.

摘要

本病例报告了一名来自中国东部的74岁女性,出现记忆力减退、计算障碍、语言障碍,被诊断为阿尔茨海默病,并接受了颈深部静脉淋巴管吻合术。经过严格的术前评估、手术治疗及术后护理,患者未出现与术后护理相关的并发症,且语言和自我护理能力有明显改善。与术前相比,患者术后3个月的简易精神状态检查表评分有所提高(从0分提高到5分)。本病例说明了相关手术在治疗阿尔茨海默病方面的潜力,并强调适当的医疗和护理对于更好的康复至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34a/12102557/d24ab3dc4420/10.1177_25424823251342487-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34a/12102557/f8609ba79f30/10.1177_25424823251342487-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34a/12102557/d24ab3dc4420/10.1177_25424823251342487-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34a/12102557/f8609ba79f30/10.1177_25424823251342487-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34a/12102557/d24ab3dc4420/10.1177_25424823251342487-fig2.jpg

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本文引用的文献

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Promising outcomes 5 weeks after a surgical cervical shunting procedure to unclog cerebral lymphatic systems in a patient with Alzheimer's disease.在一名阿尔茨海默病患者身上进行手术性颈部分流手术以疏通脑淋巴系统5周后出现了有希望的结果。
Gen Psychiatr. 2024 Jun 22;37(3):e101641. doi: 10.1136/gpsych-2024-101641. eCollection 2024.
2
A Retrospective Comparison Trial Investigating Aggregate Length of Stay Post Implementation of Seven Enhanced Recovery After Surgery (ERAS) Protocols between 2015 and 2022.一项回顾性比较试验,调查2015年至2022年间实施七种术后加速康复(ERAS)方案后的总住院时长。
J Clin Med. 2024 Sep 30;13(19):5847. doi: 10.3390/jcm13195847.
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Leveraging the glymphatic and meningeal lymphatic systems as therapeutic strategies in Alzheimer's disease: an updated overview of nonpharmacological therapies.
利用糖质分解和脑膜淋巴管系统作为阿尔茨海默病的治疗策略:非药物治疗的最新综述。
Mol Neurodegener. 2023 Apr 20;18(1):26. doi: 10.1186/s13024-023-00618-3.
4
Is plasma amyloid-β 1-42/1-40 a better biomarker for Alzheimer's disease than AβX-42/X-40?血浆 Aβ1-42/1-40 作为阿尔茨海默病生物标志物优于 AβX-42/X-40 吗?
Fluids Barriers CNS. 2022 Dec 3;19(1):96. doi: 10.1186/s12987-022-00390-4.
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Development and validation of the care challenge scale in family caregivers of people with Alzheimer's disease.《阿尔茨海默病患者家庭照顾者照顾挑战量表的编制及信效度检验》
Front Public Health. 2022 Jul 28;10:921858. doi: 10.3389/fpubh.2022.921858. eCollection 2022.
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Global and regional projections of the economic burden of Alzheimer's disease and related dementias from 2019 to 2050: A value of statistical life approach.2019年至2050年全球及区域阿尔茨海默病及相关痴呆症经济负担预测:统计生命价值法
EClinicalMedicine. 2022 Jul 22;51:101580. doi: 10.1016/j.eclinm.2022.101580. eCollection 2022 Sep.
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The Prevalence of Frailty Among Older Adults Living With Dementia: A Systematic Review.老年痴呆症患者中衰弱的流行率:系统评价。
J Am Med Dir Assoc. 2022 Nov;23(11):1807-1814. doi: 10.1016/j.jamda.2022.01.084. Epub 2022 Mar 10.
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Lancet. 2021 Apr 24;397(10284):1577-1590. doi: 10.1016/S0140-6736(20)32205-4. Epub 2021 Mar 2.
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Acta Neuropathol. 2021 May;141(5):681-696. doi: 10.1007/s00401-021-02263-w. Epub 2021 Feb 20.
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J Intern Med. 2018 Dec;284(6):643-663. doi: 10.1111/joim.12816. Epub 2018 Aug 19.