Hall Alix, Doherty Emma, Nathan Nicole, Wiggers John, Attia John, Tully Belinda, Elliott Elizabeth J, Oldmeadow Christopher, Chiu Simon, Kingsland Melanie
School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia.
Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Front Med (Lausanne). 2025 May 9;12:1476083. doi: 10.3389/fmed.2025.1476083. eCollection 2025.
This is a secondary analysis of a stepped-wedge trial. The sustainment of evidence-based care is essential for ongoing population benefits. In a randomized stepped-wedge controlled trial of public maternity services across three health sectors in New South Wales, Australia, we demonstrated a positive practice change related to addressing alcohol use during pregnancy. This change followed a 7-month implementation strategy conducted between February 2018 and November 2019. However, evidence suggests that the impact of implementation strategies may reduce over time. It is important to document when and if recommended care reduces, so that timely support for sustainment can be provided.
As a secondary analysis, an interrupted time series analysis of outcomes from the largest sector of the randomized stepped-wedge controlled trial was conducted. The analysis explored the rate, time points, and extent of change in women's reported receipt of recommended antenatal care for alcohol consumption, following delivery of an effective implementation strategy.
A total of 4,909 (82% consented) women were surveyed. The proportion of pregnant women receiving recommended care reduced significantly per week following the withdrawal of implementation support, for three of the four outcomes: assessment of alcohol consumption (% change per week: -0.66, 95% CI: -1.1, -0.26); advice not to consume alcohol during pregnancy and of potential risks (% change per week: -0.63, 95% CI: -1.1, -0.22); and complete care relevant to alcohol risk level (advice and referral) (% change per week: -0.64, 95% CI: -1.1,-0.22). Similar results were observed regardless of the timing of antenatal visits. A more rapid decline occurred for most outcomes from the end of implementation until approximately 30 weeks post-implementation.
Despite a reduction in the receipt of recommended care, rates were still higher post-implementation than pre-implementation. Receipt of recommended antenatal care for alcohol consumption declined after active implementation support was withdrawn. The findings suggest the need for ongoing monitoring of care delivery and the introduction of additional sustainability strategies at key time points post-withdrawal of implementation support.
这是一项阶梯楔形试验的二次分析。循证护理的持续实施对于持续为人群带来益处至关重要。在澳大利亚新南威尔士州三个卫生部门开展的一项关于公共孕产妇服务的随机阶梯楔形对照试验中,我们证明了在解决孕期饮酒问题方面实践发生了积极变化。这一变化是在2018年2月至2019年11月期间实施的一项为期7个月的策略之后出现的。然而,有证据表明实施策略的影响可能会随着时间推移而减弱。记录推荐护理何时以及是否减少很重要,以便能够及时提供持续支持。
作为二次分析,对随机阶梯楔形对照试验中最大部门的结局进行了中断时间序列分析。该分析探讨了在实施有效策略后,女性报告接受推荐的孕期饮酒产前护理的变化率、时间点和变化程度。
共对4909名女性(82%同意参与)进行了调查。在撤销实施支持后,四项结局中有三项显示,每周接受推荐护理的孕妇比例显著下降:饮酒情况评估(每周变化百分比:-0.66,95%置信区间:-1.1,-0.26);孕期不饮酒及潜在风险的建议(每周变化百分比:-0.63,95%置信区间:-1.1,-0.22);以及与酒精风险水平相关的完整护理(建议和转诊)(每周变化百分比:-0.64,95%置信区间:-1.1,-0.22)。无论产前检查时间如何,均观察到类似结果。从实施结束到实施后约30周,大多数结局出现了更快的下降。
尽管接受推荐护理的比例有所下降,但实施后仍高于实施前。在积极的实施支持撤销后,接受推荐的孕期饮酒产前护理的比例下降。研究结果表明,需要持续监测护理提供情况,并在撤销实施支持后的关键时间点引入额外的可持续性策略。