Zhou Qilong, Gao Weijie, Zhang Weijin, Tang Shu, Fu Hongxue, Pan Pengfei
Department of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing 404100, P.R. China.
North Sichuan Medical College, Nanchong, Sichuan 637100, P.R. China.
Mol Med Rep. 2025 Aug;32(2). doi: 10.3892/mmr.2025.13573. Epub 2025 May 26.
Sepsis is characterized by a dysregulated systemic inflammatory response to infection. Despite substantial advances in its treatment, sepsis remains a significant global health burden. An understanding of the underlying mechanisms driving sepsis is crucial for the development of targeted therapeutic strategies. Silent information regulator 1 (SIRT1), a member of the class III histone deacetylases, plays a pivotal role in regulating gene expression by catalyzing the deacetylation of lysine residues on non‑histone and histone proteins. SIRT1 has been shown to exert significant anti‑inflammatory, anti‑oxidative, anti‑apoptotic and metabolic regulatory effects, making it a potential therapeutic target for sepsis. The present study reviewed the latest research progress on the signaling pathways modulated by SIRT1 in sepsis and its associated regulatory mechanisms to further elucidate the pathogenesis of sepsis and guide its clinical treatment.
脓毒症的特征是对感染的系统性炎症反应失调。尽管其治疗取得了重大进展，但脓毒症仍然是全球重大的健康负担。了解驱动脓毒症的潜在机制对于制定有针对性的治疗策略至关重要。沉默信息调节因子1（SIRT1）是III类组蛋白脱乙酰酶的成员，通过催化非组蛋白和组蛋白上赖氨酸残基的脱乙酰化在调节基因表达中起关键作用。已证明SIRT1具有显著的抗炎、抗氧化、抗凋亡和代谢调节作用，使其成为脓毒症的潜在治疗靶点。本研究综述了SIRT1在脓毒症中调节的信号通路及其相关调节机制的最新研究进展，以进一步阐明脓毒症的发病机制并指导其临床治疗。
