Liu Yu, Liang Ruoxuan, Lin Yin, Xu Benhong
College of public health, Zunyi Medical University, Zunyi, China; Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Shenzhen Futian Center for Chronic Disease Control, Shenzhen 518048, China.
J Affect Disord. 2025 Oct 1;386:119479. doi: 10.1016/j.jad.2025.119479. Epub 2025 May 24.
Obesity is recognized as a potential risk factor for depression, a prevalent psychiatric disorder that adversely impacts the health of adults globally. Based on this premise, the current study systematically examined the weight-adjusted-waist index (WWI), a more comprehensive measure of obesity, in individuals diagnosed with depression.
Following PRISMA guidelines, a thorough search was conducted across five online databases: PubMed, Scopus, Embase, ScienceDirect, and Web of Science. Following the screening process, seven studies were included, encompassing a total of 162,053 participants, of whom 47.9 % were male.
Despite some inconsistencies among the study reports, the majority of the included studies indicated elevated levels of the WWI index in patients with depression. Furthermore, meta-analytical results revealed that each 1-unit increase in the WWI index was significantly associated with higher odds of depression. Subgroup analyses indicated that this association was more pronounced in women, individuals aged 60 and above, diabetics, and those without cardiovascular disease or hypertension. Additionally, sensitivity analyses have corroborated the robustness of our findings.
The number of studies included in the study was still relatively small. In addition, there was inherent heterogeneity among the included studies.
A significant positive association was observed between the WWI index and depression. Consequently, this study underscores the imperative for continued research in this area and suggests the potential integration of the WWI index measure into standard depression screening protocols to prevent depression-related fatal outcomes in the future.
肥胖被认为是抑郁症的一个潜在风险因素，抑郁症是一种普遍存在的精神疾病，对全球成年人的健康产生不利影响。基于这一前提，本研究系统地检查了体重调整腰围指数（WWI），这是一种更全面的肥胖测量指标，用于诊断为抑郁症的个体。
按照PRISMA指南，在五个在线数据库中进行了全面搜索：PubMed、Scopus、Embase、ScienceDirect和Web of Science。经过筛选过程，纳入了七项研究，共涉及162,053名参与者，其中47.9%为男性。
尽管研究报告之间存在一些不一致之处，但大多数纳入研究表明抑郁症患者的WWI指数水平升高。此外，荟萃分析结果显示，WWI指数每增加1个单位与患抑郁症的较高几率显著相关。亚组分析表明，这种关联在女性、60岁及以上的个体、糖尿病患者以及没有心血管疾病或高血压的个体中更为明显。此外，敏感性分析证实了我们研究结果的稳健性。
纳入研究的数量仍然相对较少。此外，纳入研究之间存在内在的异质性。
观察到WWI指数与抑郁症之间存在显著的正相关。因此，本研究强调了在该领域继续开展研究的必要性，并建议将WWI指数测量潜在地纳入标准抑郁症筛查方案，以预防未来与抑郁症相关的致命后果。
