Fan Jun-Jie, Hu Can, Hu Min, Dong Wen-Sheng, Li Kang, Ye Yun-Jia, Zhang Xin
Department of Geriatrics, Renmin Hospital of Wuhan University, Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan 430060, China.
Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Clinical Research Center for Medical Imaging in Hubei Province, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
Cell Signal. 2025 Oct;134:111886. doi: 10.1016/j.cellsig.2025.111886. Epub 2025 May 24.
TRIM7, a member of the E3 ubiquitin ligase family, has garnered significant attentions in different research fields since its discovery. This enzyme plays indispensable roles in various pathophysiological processes through ubiquitination-mediated degradation of diverse protein substrates. This review systematically summarizes the current knowledge on the protein structure and biological functions of TRIM7. Structurally, TRIM7 features a conserved RBCC motif (RING, B-box, and coiled-coil domains) coupled with a variable C-terminal region that dictates the substrate specificity. In infectious contexts, TRIM7 is required for the pathogen-specific regulation, and exerts paradoxical effects by either promoting host defense or facilitating viral pathogenesis depending on pathogen type. Within oncology, TRIM7 manifests tumor-suppressive properties through regulating metastasis, apoptosis, and tumor immunology. In addition, it might serve as a reliable biomarker for monitoring the progression of idiopathic pulmonary fibrosis and also inhibits the progression of atherosclerosis. In summary, TRIM7 plays critical roles in different pathophysiological processes, and it might be a predictive and therapeutic target in certain human diseases.
TRIM7是E3泛素连接酶家族的一员，自发现以来在不同研究领域备受关注。该酶通过泛素化介导的多种蛋白质底物降解，在各种病理生理过程中发挥不可或缺的作用。本综述系统总结了目前关于TRIM7蛋白质结构和生物学功能的知识。在结构上，TRIM7具有保守的RBCC基序（RING、B盒和卷曲螺旋结构域）以及决定底物特异性的可变C末端区域。在感染情况下，TRIM7是病原体特异性调控所必需的，并且根据病原体类型，通过促进宿主防御或促进病毒发病机制发挥矛盾的作用。在肿瘤学领域，TRIM7通过调节转移、凋亡和肿瘤免疫学表现出肿瘤抑制特性。此外，它可能作为监测特发性肺纤维化进展的可靠生物标志物，还能抑制动脉粥样硬化的进展。总之，TRIM7在不同的病理生理过程中起关键作用，并且可能是某些人类疾病的预测和治疗靶点。
