探索肢端皮炎的管理。
Exploring management of acrodermatitis.
作者信息
Tang Hua, Yang Yi, Yao Fang, Xiong Qi, Yin Ming, Liao Yangying, Li Lan, Hu Feng, Li Ke
机构信息
Department of Dermatology, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), China.
Department of Dermatology, Yueyang Central Hospital, China.
出版信息
Asia Pac J Clin Nutr. 2025 Jun;34(3):332-342. doi: 10.6133/apjcn.202506_34(3).0008.
BACKGROUND AND OBJECTIVES
Acquired acrodermatitis enteropathica (AE), a rare dermatological condition, often stems from nutritional zinc deficiency linked to prolonged total parenteral nutrition (TPN). This study aims to explore the pathogenesis, clinical characteristics, and treatment approaches for AE, emphasizing the importance of early recognition and intervention.
METHODS AND STUDY DESIGN
A 51-year-old female patient with acquired AE presented with widespread erythema, pustules, and itching. A comprehensive diagnostic approach, including various tests and skin biopsy pathology, confirmed the diagnosis. Treatment involved zinc gluconate supplementation, topical applications, and symptomatic TPN support.
RESULTS
Significant im-provement was observed one week post-treatment, with reduced erythema, pustules, and skin lesions, along with improved hair loss. Erosive and ulcerative surfaces healed substantially, indicating positive treatment outcomes.
CONCLUSIONS
The successful management of adult-onset AE in this case underscores the significance of recognizing clinical features and implementing effective treatment strategies. These findings provide valuable insights for diagnosing and managing AE.
背景与目的
获得性肠病性肢端皮炎（AE）是一种罕见的皮肤病，通常源于与长期全胃肠外营养（TPN）相关的营养性锌缺乏。本研究旨在探讨AE的发病机制、临床特征和治疗方法，强调早期识别和干预的重要性。
方法与研究设计
一名51岁患有获得性AE的女性患者出现广泛红斑、脓疱和瘙痒。包括各种检查和皮肤活检病理在内的综合诊断方法确诊了该病。治疗包括补充葡萄糖酸锌、局部用药以及对症TPN支持。
结果
治疗一周后观察到显著改善，红斑、脓疱和皮肤病变减少，脱发情况改善。糜烂和溃疡表面基本愈合，表明治疗效果良好。
结论
该病例中成人起病AE的成功管理强调了识别临床特征和实施有效治疗策略的重要性。这些发现为AE的诊断和管理提供了有价值的见解。
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