Qin Bingqing, Fu Yuan, Raulin Ana-Caroline, Kong Shuangyu, Li Han, Liu Junyi, Liu Chunfeng, Zhao Jing
Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215004, China.
Chin Med J (Engl). 2025 Jun 20;138(12):1411-1423. doi: 10.1097/CM9.0000000000003627. Epub 2025 May 26.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons and the accumulation of Lewy bodies, leading to motor and nonmotor symptoms. While both genetic and environmental factors contribute to PD, recent studies highlight the crucial role of lipid metabolism disturbances in disease progression. Altered lipid homeostasis promotes protein aggregation and oxidative stress, with significant changes in lipid classes such as sphingolipids and glycerolipids observed in patients with PD. These disturbances are involved in key pathological processes, such as α-synuclein aggregation, organelle dysfunction, lipid-mediated neuroinflammation, and impaired lipid homeostasis. This review examines the relationship between lipid species and PD progression, focusing on the physiological roles of lipids in the central nervous system. It explores the mechanistic links between lipid metabolism and PD pathology, along with lipid-related genetic risk factors. Furthermore, this review discusses lipid-targeting therapeutic strategies to mitigate PD progression, emphasizing the potential of lipid modulation for effective treatment development.
帕金森病（PD）是一种神经退行性疾病，其特征是多巴胺能神经元逐渐丧失和路易小体积累，导致运动和非运动症状。虽然遗传和环境因素都与PD有关，但最近的研究强调了脂质代谢紊乱在疾病进展中的关键作用。脂质稳态改变促进蛋白质聚集和氧化应激，在PD患者中观察到鞘脂和甘油脂等脂质类别发生显著变化。这些紊乱参与了关键的病理过程，如α-突触核蛋白聚集、细胞器功能障碍、脂质介导的神经炎症和脂质稳态受损。本综述探讨了脂质种类与PD进展之间的关系，重点关注脂质在中枢神经系统中的生理作用。它探讨了脂质代谢与PD病理之间的机制联系，以及与脂质相关的遗传风险因素。此外，本综述讨论了针对脂质的治疗策略以减轻PD进展，强调脂质调节在有效治疗开发中的潜力。
