ARPC4的泛素样修饰因子1化促进片状伪足形成并促进癌症转移。 - Suppr

UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis.

作者信息

Wang Miao, Cong Yu-Sheng

机构信息

Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Zhejiang Key Laboratory of Medical Epigenetics, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou, China.

出版信息

Nat Struct Mol Biol. 2025 May 26. doi: 10.1038/s41594-025-01577-7.

DOI:10.1038/s41594-025-01577-7

PMID:40419787

Abstract

摘要

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Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development.

Nat Struct Mol Biol. 2025 Jun 30. doi: 10.1038/s41594-025-01592-8.

UFMylation in tumorigenesis: Mechanistic insights and therapeutic opportunities.

Cell Signal. 2025 May;129:111657. doi: 10.1016/j.cellsig.2025.111657. Epub 2025 Feb 13.

Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase.

Nat Struct Mol Biol. 2025 Feb 10. doi: 10.1038/s41594-025-01491-y.

UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity.

Mol Cell. 2024 Mar 21;84(6):1120-1138.e8. doi: 10.1016/j.molcel.2024.01.024. Epub 2024 Feb 19.

The UFM1 system: Working principles, cellular functions, and pathophysiology.

Mol Cell. 2024 Jan 4;84(1):156-169. doi: 10.1016/j.molcel.2023.11.034. Epub 2023 Dec 22.

UFMylation: a ubiquitin-like modification.

Trends Biochem Sci. 2024 Jan;49(1):52-67. doi: 10.1016/j.tibs.2023.10.004. Epub 2023 Nov 7.

Biochemical and mechanical regulation of actin dynamics.

Nat Rev Mol Cell Biol. 2022 Dec;23(12):836-852. doi: 10.1038/s41580-022-00508-4. Epub 2022 Aug 2.

Nucleation, stabilization, and disassembly of branched actin networks.

Trends Cell Biol. 2022 May;32(5):421-432. doi: 10.1016/j.tcb.2021.10.006. Epub 2021 Nov 23.

Discovering the landscape of protein modifications.

Mol Cell. 2021 May 6;81(9):1868-1878. doi: 10.1016/j.molcel.2021.03.015. Epub 2021 Apr 1.

Roles of the actin cytoskeleton in aging and age-associated diseases.

Ageing Res Rev. 2020 Mar;58:101021. doi: 10.1016/j.arr.2020.101021. Epub 2020 Jan 20.

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UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis.

Nat Struct Mol Biol. 2025 May 26. doi: 10.1038/s41594-025-01577-7.

Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis.

Nat Struct Mol Biol. 2025 May 26. doi: 10.1038/s41594-025-01576-8.

ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis.

J Cell Biochem. 2020 Jan;121(1):231-243. doi: 10.1002/jcb.29136. Epub 2019 Jun 12.

14-3-3ε UFMylation promotes RIG-I-mediated signaling.

bioRxiv. 2025 Mar 19:2025.03.19.644084. doi: 10.1101/2025.03.19.644084.

UFMylation promotes orthoflavivirus infectious particle production.

J Virol. 2025 Jul 22;99(7):e0065425. doi: 10.1128/jvi.00654-25. Epub 2025 Jun 3.

The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy.

Autophagy. 2025 May;21(5):996-1018. doi: 10.1080/15548627.2024.2440846. Epub 2025 Jan 22.

UFMylation: A supervisor of the HIF1α pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors.

Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2500562122. doi: 10.1073/pnas.2500562122. Epub 2025 Jul 2.

[Aurora-A overexpression promotes cervical cancer cell invasion and metastasis by activating the NF-κBp65/ARPC4 signaling axis].

Nan Fang Yi Ke Da Xue Xue Bao. 2025 Apr 20;45(4):837-843. doi: 10.12122/j.issn.1673-4254.2025.04.19.

UFMylation promotes orthoflavivirus infectious particle production.

bioRxiv. 2025 Jan 9:2025.01.09.632082. doi: 10.1101/2025.01.09.632082.

Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis.

Acta Pharmacol Sin. 2024 Dec;45(12):2672-2683. doi: 10.1038/s41401-024-01335-3. Epub 2024 Jul 15.

本文引用的文献

Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development.

Nat Struct Mol Biol. 2025 Jun 30. doi: 10.1038/s41594-025-01592-8.

UFMylation in tumorigenesis: Mechanistic insights and therapeutic opportunities.

Cell Signal. 2025 May;129:111657. doi: 10.1016/j.cellsig.2025.111657. Epub 2025 Feb 13.

Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase.

Nat Struct Mol Biol. 2025 Feb 10. doi: 10.1038/s41594-025-01491-y.

UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity.

Mol Cell. 2024 Mar 21;84(6):1120-1138.e8. doi: 10.1016/j.molcel.2024.01.024. Epub 2024 Feb 19.

The UFM1 system: Working principles, cellular functions, and pathophysiology.

Mol Cell. 2024 Jan 4;84(1):156-169. doi: 10.1016/j.molcel.2023.11.034. Epub 2023 Dec 22.

UFMylation: a ubiquitin-like modification.

Trends Biochem Sci. 2024 Jan;49(1):52-67. doi: 10.1016/j.tibs.2023.10.004. Epub 2023 Nov 7.

Biochemical and mechanical regulation of actin dynamics.

Nat Rev Mol Cell Biol. 2022 Dec;23(12):836-852. doi: 10.1038/s41580-022-00508-4. Epub 2022 Aug 2.

Nucleation, stabilization, and disassembly of branched actin networks.

Trends Cell Biol. 2022 May;32(5):421-432. doi: 10.1016/j.tcb.2021.10.006. Epub 2021 Nov 23.

Discovering the landscape of protein modifications.

Mol Cell. 2021 May 6;81(9):1868-1878. doi: 10.1016/j.molcel.2021.03.015. Epub 2021 Apr 1.

Roles of the actin cytoskeleton in aging and age-associated diseases.

Ageing Res Rev. 2020 Mar;58:101021. doi: 10.1016/j.arr.2020.101021. Epub 2020 Jan 20.

UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis.

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