Chen Qiuyi, Liu Yuhan, Yang Xin, Li Bin, Liu Lu
Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, China.
J Neuroimaging. 2025 May-Jun;35(3):e70043. doi: 10.1111/jon.70043.
Resting-state functional MRI has revealed abnormal brain activity in patients with migraine, though findings have been inconsistent. This meta-analysis utilized Seed-based d Mapping to assess variations in amplitude of low-frequency fluctuations (ALFF) and fractional amplitude of low-frequency fluctuations (fALFF). The aim was to identify common brain regions with altered spontaneous brain activity in migraine patients.
A systematic search was conducted in PubMed, Web of Science, and Embase for studies published up to August 2023, comparing spontaneous low-frequency brain activity between migraine patients and healthy controls (HCs). Jackknife sensitivity, heterogeneity, publication bias, and meta-regression analyses were performed to ensure the robustness and reliability of our findings.
Nine studies, including 708 migraine patients and HCs, were included in the analysis. Applying a highly conservative family-wise error rate correction, no significant findings were observed. However, when a less conservative threshold was used, migraine patients exhibited increased ALFF/fALFF in the left anterior thalamus and the corticospinal tract but showed decreased values in the right middle frontal gyrus. Jackknife sensitivity analysis confirmed the reproducibility of these results, while heterogeneity analysis revealed significant variability across studies, likely due to differences in study design and patient populations.
This meta-analysis provides a comprehensive synthesis of neuroimaging evidence, linking migraine to abnormal spontaneous brain activity in regions associated with pain processing and nociceptive emotional modulation. These findings enhance our understanding of migraine pathophysiology and highlight potential targets for neuromodulation therapies, offering new directions for future research and clinical interventions.
静息态功能磁共振成像已揭示偏头痛患者存在异常脑活动，尽管研究结果并不一致。本荟萃分析采用基于种子点的d映射来评估低频波动幅度（ALFF）和低频波动分数幅度（fALFF）的变化。目的是确定偏头痛患者中自发脑活动改变的共同脑区。
在PubMed、Web of Science和Embase中进行系统检索，以查找截至2023年8月发表的研究，比较偏头痛患者与健康对照（HCs）之间的自发低频脑活动。进行留一法敏感性分析、异质性分析、发表偏倚分析和荟萃回归分析，以确保我们研究结果的稳健性和可靠性。
分析纳入了9项研究，包括708名偏头痛患者和健康对照。应用高度保守的家族性错误率校正后，未观察到显著结果。然而，当使用不太保守的阈值时，偏头痛患者左侧丘脑前部和皮质脊髓束的ALFF/fALFF增加，但右侧额中回的值降低。留一法敏感性分析证实了这些结果的可重复性，而异质性分析显示各研究间存在显著差异，这可能是由于研究设计和患者群体的差异所致。
本荟萃分析提供了神经影像学证据的全面综合，将偏头痛与疼痛处理和伤害性情绪调节相关区域的异常自发脑活动联系起来。这些发现增进了我们对偏头痛病理生理学的理解，并突出了神经调节治疗的潜在靶点，为未来的研究和临床干预提供了新的方向。
