Li Feng, Lin Jinxin, Lichtfouse Eric, Qi Haifeng, Peng Lang, Yu Yangyang, Gao Li
Department of Thoracic Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212013, China.
International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, No. 28 Xianning West Rd, Xi'an 710049, China.
Biosensors (Basel). 2025 Apr 29;15(5):275. doi: 10.3390/bios15050275.
Ecosystem pollution by mercury ions (Hg) is a major health concern, yet classical analytical methods for mercury analysis are limited. This paper reviews the advances in Hg detection using DNA as recognition elements in the sensors. DNA as a recognition molecule is inexpensive, simple, and appropriate for real-time detection of Hg. This paper discusses the DNA-based sensors that were used for the detection of Hg. These can be carried out by electrochemistry, field effect transistors (FET), Raman spectroscopy, colorimetry, and fluorescence resonance energy transfer (FRET). The detection principles and the advantages of DNA in these sensors are also revealed. Finally, the paper provides an overview of prospects and potential challenges in the field.
汞离子（Hg）对生态系统的污染是一个主要的健康问题，但用于汞分析的传统分析方法存在局限性。本文综述了在传感器中使用DNA作为识别元件进行汞检测的进展。DNA作为一种识别分子价格低廉、操作简单，适用于汞的实时检测。本文讨论了用于检测汞的基于DNA的传感器。这些检测可通过电化学、场效应晶体管（FET）、拉曼光谱、比色法和荧光共振能量转移（FRET）来进行。还揭示了这些传感器中DNA的检测原理及优势。最后，本文概述了该领域的前景和潜在挑战。
