Barter Lauren, Snow Stephanie, Mujoomdar Aneil, Best Lara, French Daniel
Faculty of Medicine, Carleton Campus, Dalhousie University, 5849 University Ave., Halifax, NS B3H 4R2, Canada.
Division of Medical Oncology, Department of Internal Medicine, Halifax, NS B3H 2Y9, Canada.
Curr Oncol. 2025 Apr 25;32(5):250. doi: 10.3390/curroncol32050250.
This case report highlights the management of a delayed bronchopleural fistula (BPF) following salvage pulmonary resection to achieve local control and no radiographic evidence of disease in a patient treated with serial tyrosine kinase inhibitors (TKIs) for stage IV anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). The initial pulmonary resection was complicated by dense adhesions and an abnormally torturous pulmonary artery. Six weeks after the index surgery, the patient presented with a delayed BPF requiring decortication, repair of airway, and coverage of the bronchial stump with a serratus anterior muscle flap.
本病例报告强调了在一名接受序贯酪氨酸激酶抑制剂（TKIs）治疗的IV期间变性淋巴瘤激酶（ALK）阳性非小细胞肺癌（NSCLC）患者中，为实现局部控制且影像学无疾病证据而进行挽救性肺切除术后延迟性支气管胸膜瘘（BPF）的处理。初次肺切除因致密粘连和异常迂曲的肺动脉而复杂化。初次手术后六周，患者出现延迟性BPF，需要进行胸膜剥脱术、气道修复以及用前锯肌瓣覆盖支气管残端。
