Brown Anthony, Goñi-de-Cerio Felipe, Bilbao Ainhoa, Ribes Adrià, Fernández de Henestrosa Antonio R, Prudkin Ludmila, Perugini Paola, Foyaca Mónica
Innovation and Development, ISDIN, 08019 Barcelona, Spain.
GAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), 48170 Zamudio, Spain.
J Fungi (Basel). 2025 Apr 29;11(5):345. doi: 10.3390/jof11050345.
Onychomycosis, a fungal nail infection, affects about 4% of the global population. Current topical antifungals like ciclopirox and amorolfine have limited effectiveness, highlighting the need for better treatments. WSNS-PO is a novel water-soluble therapy designed to treat and prevent onychomycosis by enhancing nail health. This study evaluated WSNS-PO's ability to penetrate the nail plate and to treat and prevent infection by using bovine hoof membranes and human nail clippings. The anti-fungal efficacy of WSNS-PO was additionally evaluated against other dermatophytes, non-dermatophyte fungi, and yeast. The results showed that WSNS-PO effectively permeated nails and reduced and prevented the colonization of human nail fragments by ex vivo, demonstrating an efficacy comparable to ciclopirox and amorolfine. WSNS-PO also prevented the transfer of infection between nails and inhibited the fungal colonization of human skin by dermatophyte and non-dermatophyte fungi and yeast. Together, these results indicate that WSNS-PO possesses fungistatic, barrier-forming, and anti-adhesive properties, suggesting that it holds promise as an onychomycosis treatment against dermatophytes, yeast, and molds.
甲癣是一种指甲真菌感染，影响着全球约4%的人口。目前的外用抗真菌药物如环吡酮和阿莫罗芬效果有限，这凸显了对更好治疗方法的需求。WSNS-PO是一种新型水溶性疗法，旨在通过改善指甲健康来治疗和预防甲癣。本研究使用牛蹄膜和人类指甲剪屑评估了WSNS-PO穿透甲板以及治疗和预防感染的能力。此外，还评估了WSNS-PO对其他皮肤癣菌、非皮肤癣菌真菌和酵母菌的抗真菌功效。结果表明，WSNS-PO能有效渗透指甲，并在体外减少和预防人类指甲碎片的定植，显示出与环吡酮和阿莫罗芬相当的疗效。WSNS-PO还能防止指甲之间的感染传播，并抑制皮肤癣菌、非皮肤癣菌真菌和酵母菌在人体皮肤上的真菌定植。这些结果共同表明，WSNS-PO具有抑菌、形成屏障和抗黏附特性，表明它有望成为治疗皮肤癣菌、酵母菌和霉菌引起的甲癣的药物。
