Ailoaei Ștefan, Șorodoc Laurențiu, Ureche Carina, Sîtari Nicolae, Ceasovschih Alexandr, Grecu Mihaela, Sascău Radu Andy, Stătescu Cristian
Department of Cardiology, Institute for Cardiovascular Diseases "Prof. Dr. George I. M. Georgescu", 700503 Iași, Romania.
Internal Medicine Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iași, Romania.
J Cardiovasc Dev Dis. 2025 May 13;12(5):181. doi: 10.3390/jcdd12050181.
Premature ventricular complexes (PVCs) are common arrhythmias that can range from benign to clinically significant. While PVCs have been extensively studied in the general population, gender-specific differences in their characteristics, prevalence, and clinical impact remain underexplored. This study aims to investigate the unique features of PVCs in women and their potential implications for diagnosis and management.
We analyzed a cohort of female patients diagnosed with PVCs, assessing their electrocardiographic patterns, symptomatology, and clinical outcomes. Data were collected from medical records, including Holter monitoring, electrocardiograms (ECGs), and echocardiographic findings. The study also evaluated the association between PVC burden and underlying cardiac conditions.
This study analyzed 161 patients (59 females, 91 males) with PVCs, revealing significant sex-based differences. Males were older, had higher BMI, and smoked more, while females experienced more presyncope. ECGs showed greater QRS fragmentation in males. TTE and CMR found males had larger ventricles, lower EF, and more myocardial fibrosis (LGE: 59.34% vs. 37.93%). Patients with LGE were older and had worse clinical outcomes, including higher ICD implantation and hospitalization rates. Despite these structural differences, treatment efficacy was similar across groups.
This study highlights key differences in PVC characteristics among women, underscoring the need for gender-specific approaches in clinical evaluation and management. Recognizing these distinctions may aid in early diagnosis, reduce unnecessary interventions, and improve patient outcomes. Further research is warranted to explore the long-term implications of PVCs in women and optimize therapeutic strategies.
室性早搏（PVCs）是常见的心律失常，其严重程度从良性到具有临床意义不等。虽然PVCs在普通人群中已得到广泛研究，但其特征、患病率和临床影响方面的性别差异仍未得到充分探索。本研究旨在调查女性PVCs的独特特征及其对诊断和管理的潜在影响。
我们分析了一组被诊断为PVCs的女性患者队列，评估她们的心电图模式、症状和临床结局。数据从病历中收集，包括动态心电图监测、心电图（ECG）和超声心动图检查结果。该研究还评估了PVC负荷与潜在心脏疾病之间的关联。
本研究分析了161例患有PVCs的患者（59例女性，91例男性），发现了显著的性别差异。男性年龄较大，体重指数较高，吸烟更多，而女性则更多地经历前驱晕厥。心电图显示男性的QRS波碎裂更严重。经胸超声心动图（TTE）和心脏磁共振成像（CMR）发现男性的心室更大，射血分数（EF）更低，心肌纤维化更多（延迟强化：59.34%对37.93%）。有延迟强化的患者年龄较大，临床结局较差，包括更高的植入式心律转复除颤器（ICD）植入率和住院率。尽管存在这些结构差异，但各组的治疗效果相似。
本研究突出了女性PVC特征的关键差异，强调在临床评估和管理中需要采用针对性别的方法。认识到这些差异可能有助于早期诊断，减少不必要的干预，并改善患者结局。有必要进一步研究以探索PVCs对女性的长期影响并优化治疗策略。
