Sabattini Elisa, Van Kerrebroeck Helena, Gyselaers Wilfried
Department Obstetrics and Gynecology, Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Department Gynecology and Obstetrics, Ziekenhuis Oost Limburg, 3600 Genk, Belgium.
J Cardiovasc Dev Dis. 2025 May 18;12(5):193. doi: 10.3390/jcdd12050193.
(1) Background: Maternal venous hemodynamic dysfunction is an intrinsic part of the pathophysiology of pre-eclampsia and fetal growth restriction. The aim of this study is to evaluate whether venous hemodynamic dysfunction is present in women with a history of (unexplained) recurrent miscarriage, and to link this pilot observation to reported data in the literature. (2) Methods: A retrospective search of hospital records was conducted to find data on recurrent miscarriage and hemodynamics assessment prior to conception. We also performed a scoping search of the literature regarding the association between recurrent miscarriage and maternal hemodynamics, reproductive outcomes, maternal complications, neonatal complications, and long-term cardiovascular function in women and their offspring. (3) Results: Six out of nine women with a history of recurrent miscarriage had preconception venous hemodynamic dysfunction. This observation is in line with the reported data on reduced venous reserves in association with low plasma volume in women with recurrent miscarriage, and adds to the reported link between recurrent miscarriage, poor reproductive outcomes, and chronic cardiovascular disease. (4) Discussion: This retrospective observational cohort supports an association between venous hemodynamic dysfunction and recurrent miscarriage that is corroborated by data reported in the literature. Abnormal venous hemodynamic function can be improved before conception, and this opens a new and currently unexplored pathway in the management of recurrent miscarriage.
(1) 背景：母体静脉血流动力学功能障碍是先兆子痫和胎儿生长受限病理生理学的固有组成部分。本研究的目的是评估有（不明原因）复发性流产病史的女性是否存在静脉血流动力学功能障碍，并将这一初步观察结果与文献报道的数据联系起来。(2) 方法：对医院记录进行回顾性检索，以查找复发性流产和受孕前血流动力学评估的数据。我们还对关于复发性流产与母体血流动力学、生殖结局、母体并发症、新生儿并发症以及女性及其后代长期心血管功能之间关联的文献进行了范围界定检索。(3) 结果：9例有复发性流产病史的女性中有6例在受孕前存在静脉血流动力学功能障碍。这一观察结果与文献报道的复发性流产女性静脉储备减少及血浆量低的数据一致，并补充了复发性流产、不良生殖结局和慢性心血管疾病之间已报道的联系。(4) 讨论：这项回顾性观察队列研究支持静脉血流动力学功能障碍与复发性流产之间的关联，文献报道的数据也证实了这一点。受孕前可改善异常的静脉血流动力学功能，这为复发性流产的管理开辟了一条新的、目前尚未探索的途径。
