Jablonsky G, Leung F Y, Henderson A R
Clin Chem. 1985 Oct;31(10):1621-4.
It is known that the ratio of isoenzyme 1 to total lactate dehydrogenase (LD, EC 1.1.1.27) in serum is increased in all patients with acute myocardial infarction within 24 h of the infarct. We now show that the LD-1/LD-2 ratio for serum more promptly indicates acute myocardial infarction, being for most patients equivalent to measurement of creatine kinase (EC 2.7.3.2) isoenzyme 2 (CK-2, CK-MB) in serum. Of 128 patients with a confirmed diagnosis of myocardial infarction, 66 had normal values for all "cardiac" enzymes at the time of admission, but greater than 75% of them showed a parallel increase in values for CK-2 and the LD-1/LD-2 ratio. Of the 26 patients who had one or more abnormal values for cardiac enzymes on admission, 95% showed a parallel increase in CK-2 and the LD-1/LD-2 ratio, the median time for the beginning of these changes being 9 h from the onset of chest pain. The remaining 36 patients were excluded from the study because CK-2 decreased after admission or because the time of onset of chest pain was uncertain.
已知在所有急性心肌梗死患者梗死24小时内，血清中同工酶1与总乳酸脱氢酶（LD，EC 1.1.1.27）的比值会升高。我们现在表明，血清中的LD-1/LD-2比值能更迅速地指示急性心肌梗死，对大多数患者而言，等同于血清中肌酸激酶（EC 2.7.3.2）同工酶2（CK-2，CK-MB）的检测结果。在128例确诊为心肌梗死的患者中，66例入院时所有“心脏”酶的值均正常，但其中超过75%的患者CK-2值与LD-1/LD-2比值呈平行升高。在入院时心脏酶有一项或多项异常值的26例患者中，95%的患者CK-2值与LD-1/LD-2比值呈平行升高，这些变化开始的中位时间为胸痛发作后9小时。其余36例患者被排除在研究之外，原因是入院后CK-2下降或胸痛发作时间不确定。
